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    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
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    • 2005 Dissertations (MU)
    • 2005 MU dissertations - Access restricted to UM
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    Interactions of porcine reproductive and respiratory syndrome virus with innate immune responses

    Lee, Sang-Myeong, 1975-
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    [PDF] research.pdf (1.551Mb)
    Date
    2005
    Format
    Thesis
    Metadata
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    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] North American field isolates of PRRSV differed in their type I IFN response with respect to induction, sensitivity and suppression. Furthermore, one PRRSV isolate strongly enhanced polyI:C - induced IFN-[alpha] production in PAM cultures and this priming effect was suppressed by other PRRSV isolates. PRRSV activates NF-[kappa]B which is a critical regulator of innate and adaptive immune function. NF-[kappa]B activation was dependent on virus replication and I[kappa]B[alpha] degradation. ROS production was involved in NF-[kappa]B activation by PRRSV. NF-[kappa]B dependent expression of MMP-2 and MMP-9 suggested a possible role of the NF-[kappa]B pathway in PRRSV pathogenesis and the immune response. PRRSV infection induced both intrinsic and extrinsic apoptosis pathways and linked these two pathways via Bid cleavage by caspase-8. While apoptosis was significantly suppressed by caspase inhibitors, the same inhibitors did not affect PRRSV replication. This study also provided evidence of a possible involvement of NF-[kappa]B and ROS in apoptosis induced by PRRSV.
    URI
    https://hdl.handle.net/10355/5817
    https://doi.org/10.32469/10355/5817
    Degree
    Ph. D.
    Thesis Department
    Veterinary pathobiology area program (MU)
    Rights
    Access is limited to the campuses of the University of Missouri.
    Collections
    • 2005 MU dissertations - Access restricted to UM
    • Veterinary Pathobiology electronic theses and dissertations (MU)

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