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dc.contributor.advisorKleiboeker, Steven B.eng
dc.contributor.authorLee, Sang-Myeong, 1975-eng
dc.date.issued2005eng
dc.date.submitted2005 Falleng
dc.description"December 2005"eng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (Ph. D.) University of Missouri-Columbia 2005.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary pathobiology area program.eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] North American field isolates of PRRSV differed in their type I IFN response with respect to induction, sensitivity and suppression. Furthermore, one PRRSV isolate strongly enhanced polyI:C - induced IFN-[alpha] production in PAM cultures and this priming effect was suppressed by other PRRSV isolates. PRRSV activates NF-[kappa]B which is a critical regulator of innate and adaptive immune function. NF-[kappa]B activation was dependent on virus replication and I[kappa]B[alpha] degradation. ROS production was involved in NF-[kappa]B activation by PRRSV. NF-[kappa]B dependent expression of MMP-2 and MMP-9 suggested a possible role of the NF-[kappa]B pathway in PRRSV pathogenesis and the immune response. PRRSV infection induced both intrinsic and extrinsic apoptosis pathways and linked these two pathways via Bid cleavage by caspase-8. While apoptosis was significantly suppressed by caspase inhibitors, the same inhibitors did not affect PRRSV replication. This study also provided evidence of a possible involvement of NF-[kappa]B and ROS in apoptosis induced by PRRSV.eng
dc.identifier.merlinb61086617eng
dc.identifier.oclc177207048eng
dc.identifier.urihttps://hdl.handle.net/10355/5817
dc.identifier.urihttps://doi.org/10.32469/10355/5817eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.subject.lcshPorcine reproductive and respiratory syndrome -- Immunologyeng
dc.subject.lcshSwine -- Virus diseaseseng
dc.subject.lcshNF-kappa B (DNA-binding protein)eng
dc.subject.lcshActive oxygeneng
dc.titleInteractions of porcine reproductive and respiratory syndrome virus with innate immune responseseng
dc.typeThesiseng
thesis.degree.disciplineVeterinary pathobiology area program (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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