dc.contributor.advisor | Hoffman, Timothy Joseph, 1958- | eng |
dc.contributor.author | Winkelmann, Christopher Todd, 1971- | eng |
dc.date.issued | 2005 | eng |
dc.date.submitted | 2005 Fall | eng |
dc.description | The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. | eng |
dc.description | Vita. | eng |
dc.description | "December 2005" | eng |
dc.description | Includes bibliographical references. | eng |
dc.description | Thesis (Ph. D.) University of Missouri-Columbia 2005. | eng |
dc.description | Dissertations, Academic -- University of Missouri--Columbia -- Veterinary pathobiology area program. | eng |
dc.description.abstract | [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Non-invasive imaging techniques have been recently developed to characterize animal models of disease. The overarching hypothesis of this work explores the use of three micro-imaging modalities, including Micro-CT, PET and SPECT, to characterize tumor anatomical progression, metabolism, bone lesion remodeling, and/or gastrin releasing peptide receptor expression in mouse models of metastatic melanoma and prostate and breast cancer bone metastasis. Micro-CT was shown to provide excellent anatomical information about tumor progression in several different tissues including lung, bone, and subcutaneous tissues. Micro-PET imaging demonstrated increased tumor metabolism in melanoma tumors, but was not able to discern bone remodeling in breast cancer bone lesions. Micro-SPECT imaging demonstrated gastrin-releasing peptide receptor expression in a prostate cancer bone metastasis model. The results from this work demonstrate the ability of micro-imaging technologies to non-invasively probe mouse models of disease to obtain information in vivo that is not possible with ex vivo experimental techniques. | eng |
dc.identifier.merlin | b56450618 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/5820 | |
dc.identifier.uri | https://doi.org/10.32469/10355/5820 | eng |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.rights | Access is limited to the campuses of the University of Missouri. | eng |
dc.subject.lcsh | Cancer -- Animal models | eng |
dc.subject.lcsh | Metastasis | eng |
dc.subject.lcsh | Tomography, Emission | eng |
dc.subject.lcsh | Single-photon emission computed tomography | eng |
dc.subject.lcsh | Tomography | eng |
dc.title | Micro-imaging characterization of mouse models of metastasis | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Veterinary pathobiology area program (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Doctoral | eng |
thesis.degree.name | Ph. D. | eng |