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    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
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    • 2005 Dissertations (MU)
    • 2005 MU dissertations - Access restricted to UM
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    Discrete NaI(TI) crystal detector optimization for small animal SPECT molecular imaging

    Daibes Figueroa, Said, 1977-
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    [PDF] research.pdf (4.421Mb)
    Date
    2005
    Format
    Thesis
    Metadata
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    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Dual-modality imaging instrumentation has allowed the noninvasive analysis of preclinical models of human disease. A combined microSPECT/CT unit (Siemens) equipped with dual discrete crystal SPECT detectors was under performance evaluation in our laboratory for SPECT molecular imaging. The CT component consists of a CCD x-ray detector and a micro-focus x-ray source (40 [mu] m focal spot). MicroSPECT performance was assessed thru characteristics measurements and high resolution phantoms. Gamma camera SPECT properties investigated using Tc-99m included system photon sensitivity, detection efficiencies, detector uniformity, spectral energy resolution, spatial resolution (FWHM), count rate, and tomograhic pre-clinical performance employing a 3D-OSEM algorithm with geometrical misalignment corrections. Camera gamma-ray sensitivity was calculated to be 3.5, 37 and 73 cps/[mu] Ci for the 0.5, 2 and 3 mm pinhole apertures, respectively. Intrinsic uniformity for the central field of view was 1.42% differential and 2.99% integral. Energy spectral resolution (FWHM) at 140 keVwas 14.3% [plus or minus]1.5 %. Volumetric spatial resolution of 1.2 mm was achieved with a hot-rod Tc-99m SPECT micro-phantom. Camera count rate linearity was achieved up to 1 mCi. In-vivo osteoblastic bone lesions 0.6 mm in diameter measured by CT were also detectable with SPECT Tc-99m-HDP imaging. Spatial resolution (FWHM) results suggest that the microCAT II® SPECT unit is capable of sub-millimeter resolution, however, photon sensitivity improvements either by employing multi-pinhole collimation and/or larger crystal elements will significantly enhance the SPECT pre-clinical performance of the unit.
    URI
    https://hdl.handle.net/10355/5821
    https://doi.org/10.32469/10355/5821
    Degree
    Ph. D.
    Thesis Department
    Nuclear engineering (MU)
    Rights
    Access to files is limited to the campuses of the University of Missouri.
    Collections
    • 2005 MU dissertations - Access restricted to UM
    • Nuclear Science and Engineering Institute electronic theses and dissertations (MU)

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