Consumer and descriptive analysis of flavored omeprazole oral suspensions

Abstract

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Gastroesophageal reflux disease or GERD, a common and widely prevalent gastro intestinal disease in US population. Lack of suitable liquid dosage forms, palatability and compliance issues are severe limitations for the effective use of omeprazole, an immediately release proton pump inhibitor (PPI) in pediatric patients, children and critically ill patients wit h GERD. This study was aimed to evaluate and compare four newly developed flavored omeprazole oral suspensions with two other commercially available formulations for their palatability and to understand the product characteristics of new formulations using sensory consumer and descriptive methods. A total of 54 supertasters who are genetically sensitive to bitterness, evaluated all the six flavored omeprazole oral suspensions for their acceptance and preference. The analysis of variance (ANOVA) of acceptance data revealed significant differences among the six flavored suspensions. Consumer preference data ana lysis reveals no significant differences between Strawberry cream without omeprazole, Zegerid [trademark symbol TM] and Tutifruti products. Descriptive data analyses by multivariate statistical tools showed that "sweetness" and "aftertaste sweetness" have strong influence in the overall liking of the products and were strongly correlated with Strawberry cream without omeprazole and Tutifruti products.