Voxel based beta particle dosimetry methods in mice

Abstract

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Radionuclide therapy cancer agents require dose information to determine efficacy in preliminary animal studies. Patient specific techniques for radionuclide transport simulation adapted from external beam dosimetry methodologies are developing currently. Dosimetry from Monte Carlo algorithms is an estimate of energy deposition based on source radionuclide and geometry configuration. These estimates result in organ specific radionuclide absorbed fractions [and S-factors] that are central to the dosimetry estimates from the MIRD schema. This work compares the results of a patient specific technique to stylized mathematical models in the literature for potential therapeutic beta emitters in mouse studies. Patient specific results have been obtained and validated for self-absorption against previous methods. These new results demonstrate progress in cross organ absorbed fractions by accurately modeling actual anatomical geometry. This particular adaptation has the potential of characterizing dose for combined radionuclide and external beam therapy.