dc.contributor.author | Daly, Sarah | eng |
dc.contributor.author | Allison, Cami | eng |
dc.contributor.author | Nashelsky, Joan | eng |
dc.date.issued | 2016 | eng |
dc.description.abstract | Q: Does vitamin D without calcium reduce fracture risk? Evidence-based answer: No. Supplemental vitamin D without calcium -- in doses averaging as much as 800 IU per day -- doesn't reduce the risk of hip, vertebral, or nonvertebral fractures in postmenopausal women and older men (strength of recommendation [SOR]: A, large, high-quality meta-analysis of randomized or quasirandomized placebo-controlled trials). The vitamin D analogs alfacalcidol and calcitriol also don't reduce hip or nonvertebral fractures (SOR: A, multiple randomized, controlled trials [RCTs]), although alfacalcidol (but not calcitriol) does reduce vertebral fractures by 43% (SOR: B, one RCT and one quasi-randomized trial with potential for bias) Vitamin D supplementation, with or without calcium, doesn't affect mortality. It does double the risk of mild hypercalcemia (about 2.7 mmol/L increase), raise the risk of renal calculi or mild renal insufficiency by 16%, and slightly increase (4%) gastrointestinal adverse effects (SOR: A, meta-analysis of RCTs or quasi-randomized trials). | eng |
dc.identifier.uri | https://hdl.handle.net/10355/59115 | eng |
dc.language | English | eng |
dc.publisher | Family Physicians Inquiries Network | eng |
dc.relation.ispartofcollection | Clinical Inquiries, 2016 (MU) | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. School of Medicine. Department of Family and Community Medicine. Family Physicians Inquiries Network | eng |
dc.relation.ispartofseries | Journal of family practice, 65, no. 12 (December 2016): 933-934. | eng |
dc.rights | OpenAccess. | eng |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. | eng |
dc.subject | vitamin D ; calcium ; elderly ; postmenopausal ; fracture risk ; fractures | eng |
dc.title | Does vitamin D without calcium reduce fracture risk? | eng |
dc.type | Article | eng |