Are SNRIs effective for pain in fibromyalgia?
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Are SNRIs effective for pain in fibromyalgia? EVIDENCE-BASED ANSWER: In patients with fibromyalgia, treatment with the serotonin-norepinephrine reuptake inhibitors (SNRIs) milnacipran and duloxetine results in 30% to 37% of patients reporting a pain reduction of 50% or more (vs 20%-24% with placebo), but mean differences in pain scores compared with placebo are small. Long-term effectiveness and optimal dosing are uncertain (SOR: B, 2 meta-analyses of RCTs without clear recommendation for use).
Evidence-based practice 19, no. 12 (2016): 10-11