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    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
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    • 2007 Dissertations (MU)
    • 2007 MU dissertations - Access restricted to MU
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    Immunity in the newborn : control by IL-13 receptor and dendritic cells

    Lee, Hyun-Hee, 1972-
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    [PDF] research.pdf (2.160Mb)
    Date
    2007
    Format
    Thesis
    Metadata
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    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Neonates are susceptible to microbial infections and allergic reactions due to lack of Th1 immunity. Utilization of a TCR transgenic T cell transfer system, we demonstrated that primary neonatal Th1 cells develop alongside Th2 cells upon priming of the newborn but undergo apoptosis upon recall with antigen. These Th1 cells were isolated, and their death was correlated with elevated IL-13R[alpha]1 chain expression. Our data suggested that IL-4 might use this receptor chain to signal for the apoptosis of Th1 cells leading to lack of Th1 immunity in neonates. The point at which neonates no longer exhibit a Th2 biased immune response has not been studied. Interestingly, we found that antigen exposure at day 6 after birth restored the secondary Th1 response concomitantly with IL-13R[alpha]1 mRNA downregulation. Our data suggest that up-regulation of IL-13R[alpha]1 at day 1 is due to delayed maturation of the CD8[alpha]+CD4- DC subset capable of IL-12 production. CD8[alpha]+CD4- DC subset transfer to 1 day old neonates diminished IL-13R[alpha]1 expression by IL-12 secretion, leading to inhibition of Th1 apoptosis and restoration of an adult-like Th1 immunity.
    URI
    https://doi.org/10.32469/10355/5939
    https://hdl.handle.net/10355/5939
    Degree
    Ph. D.
    Thesis Department
    Microbiology (Medicine) (MU)
    Rights
    Access is limited to the campus of the University of Missouri--Columbia.
    Collections
    • 2007 MU dissertations - Access restricted to MU
    • Molecular Microbiology and Immunology electronic theses and dissertations (MU)

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