What are appropriate initial tests when evaluating a patient for possible pheochromocytoma?
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What are appropriate initial tests when evaluating a patient for possible pheochromocytoma? EVIDENCE-BASED ANSWER: The most accurate initial test for suspected pheochromocytoma is plasma-free metanephrines, with a sensitivity of 94% to 99% and a specificity of 89% to 96% (positive likelihood ratio [LR+] 9-23, negative likelihood ratio [LR-0 0.01-0.067). An acceptable alternative, especially when attempting to rule out the disease, is urine-fractionated metanephrines, with a sensitivity of 97% and a specificity 69% (LR+ 3.1, LR- 0.04) (SOR: A, diagnostic cohort studies and practice guideline).
Evidence-based practice 20, no. 1 (2017): 10-11