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dc.contributor.advisorLin, Mengshi, 1973-eng
dc.contributor.advisorMustapha, Azlineng
dc.contributor.authorNguyen, Trang Ha Dieu, 1983-eng
dc.date.issued2016eng
dc.date.submitted2016 Falleng
dc.descriptionThesis supervisors: Drs. Mengshi Lin, Azlin Mustapha.eng
dc.descriptionIncludes vita.eng
dc.description.abstractThere has been increasing application of novel nanomaterials in recent years in the area of agriculture and food science. This dissertation aims to study novel nanomaterials and investigate their applications in food safety, and to develop and use surface-enhanced Raman spectroscopy (SERS) as a rapid, simple, and sensitive analytical method to improve food safety. There have been increasing applications of nanomaterials in various areas, which may cause human exposure and environmental pollution. Therefore, it is important to study the toxicity of different nanomaterials against bacteria and human cells. The objectives of this study were to: (1) develop new types of substrate consisting of monolayer graphene, gold film, and/or gold nanorod structures; (2) detect and measure silver nanoparticles (Ag NPs) in consumer products using SERS and aminothiophenol as an indicator molecule; (3) investigate the effect of graphene oxide (GO) on human intestinal bacteria and human intestinal cells; (4) study the antimicrobial activity of selenium nanoparticles (Se NPs) against foodborne pathogens and the toxicity of Se NPs against Caco-2 cells. A simple, fast, and efficient method was developed to fabricate new SERS substrates by coating a gold nanorod-decorated graphene sheet on silicone substrate. The results demonstrate that GO is biocompatible and has a potential to be used in agriculture and food science, indicating that more studies are needed to exploit its potential applications. The data show that Se NPs can be used as an antimicrobial agent to inhibit the growth of Staphylococcus aureus in foods and can potentially be used as a chemopreventative and chemotherapeutic agent. More studies are needed to elucidate the mechanisms of Se NPs and GO's cytotoxicity and their antibacterial properties. More research is also needed to improve the performance of SERS substrates using different materials and use them in improving food safety.eng
dc.description.bibrefIncludes bibliographical references (pages 132-168).eng
dc.format.extent1 online resource (xii, 169 pages) : illustrationseng
dc.identifier.merlinb118917419eng
dc.identifier.oclc992996073eng
dc.identifier.urihttps://hdl.handle.net/10355/59772
dc.identifier.urihttps://doi.org/10.32469/10355/59772eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccesseng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.eng
dc.subject.FASTFood -- Biotechnology -- Safety measureseng
dc.subject.FASTNanostructured materialseng
dc.subject.FASTNanotechnology -- Researcheng
dc.subject.FASTRaman spectroscopyeng
dc.titleAntibacterial, plasmonic, and toxic properties of engineered nanoparticleseng
dc.typeThesiseng
thesis.degree.disciplineFood science (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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