Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2007 Dissertations (MU)
    • 2007 MU dissertations - Access restricted to UM
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2007 Dissertations (MU)
    • 2007 MU dissertations - Access restricted to UM
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Efficacy of TNF inhibitor treatment in a model of heart failure and resulting cachexia

    Steffen, Brian
    View/Open
    [PDF] public.pdf (6.641Kb)
    [PDF] short.pdf (278.9Kb)
    [PDF] research.pdf (1022.Kb)
    Date
    2007
    Format
    Thesis
    Metadata
    [+] Show full item record
    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The aim this dissertation was to explore the efficacy of tumor necrosis factor (TNF) inhibitors in attenuating increases in both anorexia and the ubiquitin proteasome pathway transcripts in cardiac cachexia, a potentially lethal condition that responds poorly to current treatments. Right heart failure and subsequent cardiac cachexia was rapidly induced with monocrotaline injection in Sprague-Dawley rats and either soluble TNF receptor-1 or the general inhibitor of TNF production, pentoxifylline, was given to diminish TNF action upon the first indication of cachexia. Ubiquitin proteasome pathway transcripts and western blotting were analyzed in skeletal muscle. Both soluble TNF receptor-1 and pentoxifylline attenuated losses in both body weight and skeletal muscle mass and also reduced the transcriptional activation of the ubiquitin proteasome pathway. The action of soluble TNF receptor-1 was partly through reversal of reduced food consumption, while the effects pentoxifylline were independent of food intake. The following dissertation shows that not only does soluble TNF receptor-1 treatment attenuate anorexia in monocrotaline-induced cardiac cachexia, but that this anti-anorectic effect is responsible for attenuating the induction of some ubiquitin proteasome pathway transcripts as well as preserving body weight and skeletal muscle mass. Though further investigation is needed, sTNFR1 may have clinical efficacy in combating cachectic states brought on by heart failure.
    URI
    https://hdl.handle.net/10355/6001
    https://doi.org/10.32469/10355/6001
    Degree
    Ph. D.
    Thesis Department
    Physiology (Medicine) (MU)
    Rights
    Access is limited to the campuses of the University of Missouri.
    Collections
    • 2007 MU dissertations - Access restricted to UM
    • Medical Pharmacology and Physiology electronic theses and dissertations (MU)

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems