Browsing 2017 UMKC Dissertations - Access Restricted to UMKC by Thesis Department "Cell Biology and Biophysics (UMKC)"
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Biochemical and Structural Studies of the Role of FKBP(L)s in the fly and Mammalian Circadian Cycle
(University of Missouri -- Kansas City, 2017)FK506 binding-like proteins (FKBPLs) are proteins that structurally resemble the immunophilins. Their functions in cell signaling include protein folding, molecular trafficking, RNA splicing and cell cycle regulation ... -
A Genetic Screen for Tribbles Suppressors Identifies the E3 Ubiquitin Ligase Neuralized as a Novel Target
(University of Missouri -- Kansas City, 2017)In this dissertation, I used the Drosophila wing as a model tissue for a genetic screen to identify novel targets of Tribbles. Drosophila Tribbles is the founding member of a family of pseudokinases conserved between ... -
Modulation of calcium signaling through direct and indirect actions of polyphenolic phytostilbenes on neuronal calcium channels
(University of Missouri--Kansas City, 2017)Today in the United States there are 6.5 million people affected by a neurodegenerative disease. Recent findings hypothesize that calcium dyshomeostasis and reactive oxygen species contribute to the progression of many ... -
Structural Basis for the Regulation of the Ceramide Transfer Protein
(University of Missouri -- Kansas City, 2017)Ceramide, a central intermediate in sphingolipid metabolism, is synthesized at the endoplasmic reticulum (ER) and transferred to the Golgi by the ceramide transfer (CERT) protein for conversion to sphingomyelin (SM). ...