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dc.contributor.advisorHardin, Christopher D.eng
dc.contributor.authorHernandez, Mark J. (Mark Jerry), 1979-eng
dc.date.issued2007eng
dc.date.submitted2007 Summereng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionVita.eng
dc.description"August 2007"eng
dc.descriptionThesis (Ph. D.) University of Missouri-Columbia 2007.eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The role of membrane caveolae in the compartmentation of membrane glycolytic metabolism indicates a pivotal role of caveolin in the localization of glycolytic enzymes to this membrane domain. This dissertation demonstrates the following about the role of protein scaffold caveolin-1 (CAV-1) in the compartmentation of membrane glycolytic metabolism. 1) CAV-1 a scaffold of phosphofructokinase (PFK) can also target other glycolytic enzymes such as aldolase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and pyruvate kinase (PK) to the membrane of lymphocytes transfected with caveolin-1 (CAV-1). 2) CAV-1 is subject to regulation during enhanced glycolytic metabolism in astrocytes after 24 hour exposure to high NH4Cl. 3) The caveolin-1 scaffolding domain (CSD) is essential for the targeting of glycolytic enzyme PFK to the cell membrane in the vascular smooth muscle cell line A7r5. This dissertation addressed these three fundamental roles of caveolin-1 that support the essential role of caveolins in the organization of membrane associated glycolytic metabolism.eng
dc.description.bibrefIncludes bibliographical referenceseng
dc.identifier.merlinb61468599eng
dc.identifier.oclc182537955eng
dc.identifier.urihttps://doi.org/10.32469/10355/6007eng
dc.identifier.urihttps://hdl.handle.net/10355/6007
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.subject.lcshMuscle cellseng
dc.subject.lcshMembrane proteins -- Biosynthesiseng
dc.subject.lcshCell membraneseng
dc.subject.lcshEnzymologyeng
dc.subject.lcshGlycolysis -- Physiologyeng
dc.subject.meshCaveolin 1 -- biosynthesiseng
dc.subject.meshCell Membrane -- enzymologyeng
dc.subject.meshGlycolysis -- physiologyeng
dc.subject.meshMyocytes, Smooth Muscle -- enzymologyeng
dc.titleCaveolin-1 A scaffold for microcompartmental organization of membrane-associated glycolysiseng
dc.typeThesiseng
thesis.degree.disciplinePhysiology (Medicine) (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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