What dose of thiamine should be used for prevention of Wernicke’s encephalopathy?
What dose of thiamine should be used for prevention of Wernicke's encephalopathy? Evidence-based answer: No consensus exists regarding the specific dose of thiamine that should be given for prevention of Wernicke's encephalopathy. Surrogate outcome measures for prevention of Wernicke-Korsakoff syndrome suggest 200 mg intramuscularly (IM) daily for 2 days is better than 5 mg IM for 2 days (SOR: B, RCT). It is recommended that more than 25 mg/d should be given parentally for at least 5 days followed by oral therapy (SOR: C, consensus guideline).
Evidence-based practice 20, no. 7 (2017): 12-13