What are the health risks of using insulin in patients with type 2 diabetes?
What are the health risks of using insulin in patients with type 2 diabetes? Evidence-based answer: Despite its effectiveness in improving blood sugar control, high-intensity insulin use is associated with more episodes of hypoglycemia (SOR: A, systematic review of RCTs). Compared with sulfonylureas plus metformin, insulin plus metformin is associated an excess of 11 deaths per 1,000 person-years (SOR: B, retrospective cohort). The evidence is conflicting about an association between insulin use and colorectal cancer (no SOR given).
Evidence-based practice 20, no. 4 (2017): E10