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dc.contributor.advisorSharpe-Timms, Kathy L.eng
dc.contributor.authorStilley, Julie Ann Weaver, 1983-eng
dc.date.issued2008eng
dc.date.submitted2008 Falleng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on October 7, 2009)eng
dc.descriptionThesis advisor: Dr. Kathy L. Sharpe-Timms.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionAccess is limited to the campus of the University of Missouri-Columbia.eng
dc.descriptionM.S. University of Missouri-Columbia 2008.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Animal sciences.eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Endometriosis affects millions of women worldwide; its symptoms are pain and reduced fecundity. An established rat model was used which endometriosis is surgically induced (Endo) was compared to surgical controls (Sham). Tissue inhibitor of metalloproteinase (TIMPs) play a role in the pathologies of endometriosis. Endometriotic lesions secrete TIMP-1 into the peritoneal fluid of women and rats with endometriosis. We hypothesized endometriotic TIMP-1 contributes to reduced fecundity in endometriosis. Endo rats had fewer ovarian follicles and corpora lutea (CL) and the presence of luteinized unruptured follicles, and fewer oocytes and zygotes which were of poorer quality. Endo rats had reduced fecundity and only Endo rats had miscarriages. Daughters from Endo rats with no surgery had the same reproductive abnormalities which may be caused by an epigenetic factor. Endo rats have more TIMP-1 peritoneal fluid and surrounding follicles than Shams, which may interfere with ovulation. Modulation of TIMP-1 changed the reproductive phenotype. TIMP-1 treated Sham rats had the same reproductive anomalies as Endo rats, while TIMP-1 function blocking antibody treated Endo rats had a fertility phenotype like Sham rats. To test the specificity of TIMP-1 to the mechanism, control rats were treated with peritoneal fluid. Rats treated with Endo peritoneal fluid had reproductive anomalies like Endo rats, but rats treated with Endo peritoneal fluid minus TIMP-1 or Sham fluid did not. Thus, novel therapies modulating TIMP-1 may restore fecundity in women with endometriosis.eng
dc.identifier.merlinb71556874eng
dc.identifier.oclc455388849eng
dc.identifier.urihttps://hdl.handle.net/10355/6072
dc.identifier.urihttps://doi.org/10.32469/10355/6072eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campus of the University of Missouri--Columbia.eng
dc.subject.lcshFertilityeng
dc.subject.lcshEndometriosis -- Animal modelseng
dc.subject.lcshMetalloproteinases -- Inhibitorseng
dc.titleTissue inhibitor of metalloproteinase-1 contributes to reduced fecundity in a rat model of endometriosiseng
dc.typeThesiseng
thesis.degree.disciplineAnimal sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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