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    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Theses (MU)
    • 2016 Theses (MU)
    • 2016 MU theses - Access restricted to MU
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    The role of CFTR in regulating the cell cycle of intestinal stem cells

    Stefanski, Casey
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    [PDF] public.pdf (1.624Kb)
    [PDF] research.pdf (967.4Kb)
    [PDF] short.pdf (5.841Kb)
    Date
    2016
    Format
    Thesis
    Metadata
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    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] [Abstract taken from public pdf.] Cystic fibrosis (CF) patients and CF mouse models have an increased risk for gastrointestinal (GI) cancer. Intestinal stem cells (ISCs) are thought to drive GI cancer potentially due to ISC abnormally rapid cell divisions or hyperproliferation. Elevated intracellular chloride can facilitate the transition of ISC from a resting state to a proliferating state. Previous studies have shown the CF epithelium sustains elevated intracellular chloride. Elevated intracellular chloride can result in a decrease in p21 expression, an important repressor of proliferation. It was concluded that Cftr regulates ISC proliferation.
    URI
    https://hdl.handle.net/10355/61131
    Degree
    M.S.
    Thesis Department
    Veterinary biomedical sciences (MU)
    Rights
    Access to files is limited to the University of Missouri--Columbia.
    Collections
    • Biomedical Sciences electronic theses and dissertations (MU)
    • 2016 MU theses - Access restricted to MU

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