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dc.contributor.advisorHawthorne, M. Frederickeng
dc.contributor.advisorHarmata, Michael, 1959-eng
dc.contributor.authorLiu, Yuan, 1979-eng
dc.date.issued2008eng
dc.date.submitted2008 Falleng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on month day year)eng
dc.descriptionThesis advisor: Dr. M. Frederick Hawthorne, Dr. Michael Harmata.eng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionAccess is limited to the campuses of the University of Missouri.eng
dc.descriptionM.S. University of Missouri--Columbia 2008.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Chemistry.eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Followed by Funk's method, I synthesized silyloxyacroleins and used them as dienophiles to react with different dienes in [4+3] cycloaddition reaction. These enals such as 2-(tert-butyldimethylsilyloxy)-hept-2-eanl can undergo [4 + 3] cyclizations with different dienes in the presence of Lewis acids or Bronsted acid with excellent regio- and stereoselectivity. The reaction conditions for the synthesis dodecacarbonate-closo-dodecaborate were optimized. This carbonate closomer can be used in a drug delivery system. The stability of this dodecacarbonate-closo-dodecaborate was examined: it is stable in acid environment, but can be decomposed into 4-nitrophenol gradually in basic solutions. The solubility of this carbonate closomer was also investigated: it does not dissolve in water, but has a good solubility in diethyl ether and toluene.eng
dc.identifier.merlinb71559279eng
dc.identifier.oclc455485789eng
dc.identifier.urihttps://hdl.handle.net/10355/6114
dc.identifier.urihttps://doi.org/10.32469/10355/6114eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.subject.lcshRing formation (Chemistry)eng
dc.subject.lcshAcid-base chemistryeng
dc.subject.lcshDiolefinseng
dc.titleSynthesis of silyloxyacrolein for [4+3] cycloaddition and preparation of carbonate closomereng
dc.typeThesiseng
thesis.degree.disciplineChemistry (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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