Browsing Health Sciences Research Day (MU) by Thesis Advisor "Thakkar, Mahesh"
Now showing items 1-6 of 6
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Binge drinking causes sleep disruptions: a likelihood of hangover [abstract]
(2010-11)Binge drinking is highly prevalent in the society especially among college students. It is often followed by a period of “hangover” which is defined as general discomfort consisting of heterogeneous behavioral and psychological ... -
Chronic ethanol exposure alters epigenetic mechanism in the basal forebrain [abstract]
(2010-11)One of the most commonly observed characteristics of alcohol withdrawal is insomnia. Importantly, there is a strong association between insomnia and relapse to alcoholism. In a recent study, we have shown that insomnia in ... -
Getting over a hangover: how do wake promoting neurons in the basal forebrain affect ethanol induced sleep? [abstract]
(2010-11)Hangover is a common clinical manifestation of heavy alcohol use. Sleepiness/drowsiness is a common symptom of hangover; however its neuroanatomical substrate is unknown. The basal forebrain (BF) cholinergic neurons play ... -
Nicotine reduces adenosine release in the lateral hypothalamus: a possible mechanism of its addiction [abstract]
(2010-11)Nicotine (tobacco) addiction is a serious health issue and a leading cause of death. However, the mechanism of nicotine addiction is not fully understood. Previous reports suggest that nicotine induced activation of orexin ... -
Protracted activation of the basal forebrain cholinergic neurons after binge ethanol exposure [abstract]
(2010-11)Insomnia during alcohol withdrawal is a hallmark of alcohol dependency and a major cause of relapse in recovering alcoholics. The mechanism of insomnia in this patient population is poorly understood. Cholinergic neurons ... -
Sleep deprivation causes epigenetic changes in the basal forebrain [abstract]
(2010-11)Today's work pressure has lead people to curtail their sleep. However, all of the consequences of sleep deprivation are not clear. Histone acetylation is a key epigenetic mechanism responsible for controlling gene expression. ...