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MicroRNA mir-146a expression in oral cancer tissues [abstract]
(2010)
Recent advances in basic research have shown that the expression and function of microRNAs impact on gene expression regulation networks extensively. Ever increasing new knowledge from microRNA studies should be translated ...
Orthopaedic trauma and an aging population : a retrospective review of factors influencing outcomes [abstract]
(2010)
Orthopaedic trauma outcomes are largely dependent upon mechanism of injury. However, elderly patients often sustain lower energy trauma, but have worse outcomes. Studies have shown that elderly patients are more likely to ...
Geographic distribution of Show Me Healthy Women providers and breast cancer incidence and mortality in Missouri counties [abstract]
(2010)
Breast cancer is the second most common cause of cancer death among US women. Regular mammography is the most effective method to reduce mortality. However, uninsured women face substantial barriers to receiving regular ...
Getting over a hangover : how do wake promoting neurons in the basal forebrain affect ethanol induced sleep? [abstract]
(2010)
Hangover is a common clinical manifestation of heavy alcohol use. Sleepiness/drowsiness is a common symptom of hangover; however its neuroanatomical substrate is unknown. The basal forebrain (BF) cholinergic neurons play ...
The experience of initiating and being on dialysis among the elderly [abstract]
(2010)
Chronic kidney disease (CKD) is a disease that requires extreme treatment measures to ensure survival for the patients it afflicts. These measures include dialysis and/or kidney transplantation. Since 1973, the federal ...
Evaluation of [99mTC(CO)3]-labeled ERBB-2-targeting peptides for breast carcinoma imaging [abstract]
(2010)
The purpose of this study was to radiolabel a novel ErbB-2-avid peptide, discovered
from bacteriophage display, with [99mTc(H2 O)3 (CO)3 ]+ and evaluate the in vitro cellular targeting and in vivo tumor imaging properties ...
Nebivolol, a beta adrenergic receptor antagonist blocks angiotensin II-mediated signaling in heart [abstract]
(2010)
We recently showed that Nebivolol, a [beta]-adrenergic receptor (AR) antagonist attenuates myocardial oxidative stress and promotes insulin metabolic signaling in 9 week old Zucker obese (ZO) insulin resistant rats. Here, ...
Matrix metalloproteinase proteolysis after stroke : a surrogate indicator for early diagnosis and validation of treatment
(2010)
Matrix metalloproteinases (MMPs) are a family of endoproteaseses that have various functions from development to disease. They are also believed to play critical roles in the central nerve system for the pathogenesis of ...
Two-stage vs. single-stage management of patients with choledocholithiasis : meta analysis of randomized controlled trials [abstract]
(2010)
Current management of choledocholithiasis involves two stage process involving ERCP and laparoscopic cholecystectomy (LC). An alternative single-stage laparoscopic treatment was introduced for these patients. Various ...
Screening for male osteoporosis at an academic medical center : retrospective analysis of DXA usage patterns over 5 years [abstract]
(2010)
Recent research suggests men have higher mortality rates than women after hip fracture and men experience fractures at higher bone density values. Although the risk of osteoporotic fractures in men is increasing, there is ...
Selective review of tDCS and cognitive training studies enhancing cognitive performance in health and disease [abstract]
(2010)
Cognitive decline is an inevitable part of the normal aging process that has been shown to impact a person's functioning in daily life. Despite this, there is a lack of evidence which supports practical and effective methods ...
What is the prevalence of a bicornuate uterus and the impact it has on reproduction? [abstract]
(2010)
This research looks at how the presence of a bicornuate uterus may have an impact on reproduction. Our goal was to look at statistics and current publications and determine how great of an affect this anomaly had. We ...
Ultrasound assisted liposuction [abstract]
(2010)
The purpose of this study is to examine Ultrasound Assisted Liposuction (UAL) and compare its advantages and disadvantages with traditional liposuction procedures. UAL is a relatively new technology and concept that has ...
Ang II contributes proximal tubule remodeling in transgenic Ren2 rats [abstract]
(2010)
Activation of the renin-angiotensin system (RAS) and subsequent elevations of tissue angiotensin (Ang) II contribute to the development of proteinuria and progressive kidney disease. Recent work suggests that proximal ...
Acute (binge) administration of ethanol causes histone H3 phosphorylation at SER-10, SER-28 & gene expression in rat liver in vivo [abstract]
(2010)
Epigenetic histone modification is emerging as a critical player in the cellular actions of ethanol. In this study we have examined the effect of ethanol on histone H3 phosphorylation in vivo using an acute model. Twelve ...
Physical inactivity rapidly alters glycemic control in young, lean, previously active volunteers [abstract]
(2010)
Postprandial hyperglycemia is a better predictor of cardiovascular disease and all cause mortality than fasting blood glucose or hemoglobin A1c. Physical inactivity is associated with insulin resistance and cardiovascular ...
Coupling of spontaneous changes in muscle sympathetic nerve activity to blood pressure in humans : potential influence of age [abstract]
(2010)
Previous studies indicate a 5.5 second latency between a burst of muscle sympathetic nerve activity (MSNA) and the resultant peak blood pressure response, which averages up to 3 mmHg. Aging may attenuate α-adrenergic ...
Analysis of the cerebellum in individuals with autism spectrum disorder using magnetic resonance imaging [abstract]
(2010)
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects approximately 1 of every 150 people in the US population. Individuals with ASD have been shown to display deficits in motor coordination, suggesting ...
Plasma miRNAs as novel biomarkers for breast cancer detection [abstract]
(2010)
MicroRNAs, a family of 19- to 25-nucleotide noncoding RNAs that primarily regulate genes at post-transcriptional level, are frequently dysregulated in cancer including breast cancer. Recent studies demonstrate that the ...
Prevalence of vitamin D deficiency and insulin resistance among overweight children and adolescents : a database study
(2010)
To evaluate the associations among vitamin D levels, obesity, and insulin resistance in an adolescent cohort, a cross-sectional study was conducted using 10-18 year old adolescents enrolled in the Adolescent Diabetes and ...