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dc.contributor.authorLease, Kevineng
dc.contributor.corporatenameUniversity of Missouri--Columbia. School of Medicineeng
dc.contributor.meetingnameHealth Sciences Research Day (2010 : University of Missouri)eng
dc.date.issued2010-02eng
dc.description.abstractLiving on earth, we are exposed to ultraviolet (UV) light as part of the solar radiation. UVB spectrum light exposure contributes to the development of skin cancer by interacting with pyrimidine pairs to create lesions called cyclobutane pyrimidine dimers. If these lesions are not removed by nucleotide excision repair, they often give rise to C to T transition mutations. Based on these observations, a bioinformatics approach was used to predict the vulnerability of every human protein coding gene to UVB induced loss of function mutations. This information may help to predict additional genes involved in skin cancer.eng
dc.format.extent1 pageeng
dc.identifier.urihttp://hdl.handle.net/10355/6123
dc.languageEnglisheng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Health Sciences Research Dayeng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.eng
dc.subject.FASTBioinformaticseng
dc.subject.FASTUltraviolet radiationeng
dc.subject.FASTskin cancereng
dc.titleBioinformatic prediction of ultraviolet light mutagenesis sensitive human genes [abstract]eng
dc.typeAbstracteng


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