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dc.contributor.advisorGates, Kent S. (Kent Stephen), 1962-eng
dc.contributor.authorSeiner, Derrick R., 1981-eng
dc.date.issued2009eng
dc.date.submitted2009 Springeng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on Feb 16, 2010).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionDissertation advisor: Dr. Kent S. Gates.eng
dc.descriptionVita.eng
dc.descriptionPh. D. University of Missouri--Columbia 2009.eng
dc.description.abstractProtein tyrosine phosphatases are a class of enzymes that control a number of critical signaling pathways inside cells. We have discovered a number of dietary and endogenous agents that are capable of modifying these enzymes, and therefore disrupting signaling pathways inside cells. It is possible that these small molecules are exerting their widely reported biological effect by the modification of protein tyrosine phosphatase activity. This information is critical to our understanding of dietary effect on diseases like diabetes and cancer. In addition to this work, we have explored the chemistry of the most common DNA lesion, the abasic site. We have found it is capable of producing an interstrand crosslink in duplex DNA, when placed in the right sequence context. This work significantly expands our understanding of the toxicity of abasic sites to cells. Furthermore, this work may result in developing novel treatment strategies for cancer.eng
dc.description.bibrefIncludes bibliographical references.eng
dc.format.extentxx, 133 pageseng
dc.identifier.oclc519636234eng
dc.identifier.urihttps://hdl.handle.net/10355/6135
dc.identifier.urihttps://doi.org/10.32469/10355/6135eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.subject.lcshProtein-tyrosine phosphataseeng
dc.subject.lcshDieteticseng
dc.subject.lcshNutritioneng
dc.subject.lcshDiet in diseaseeng
dc.subject.lcshDiet therapyeng
dc.titleInactivation of protein tyrosine phosphatases by endogenous and dietary agentseng
dc.typeThesiseng
thesis.degree.disciplineChemistry (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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