Are calcium channel blockers effective for treating primary Raynaud’s phenomenon?
Are calcium channel blockers effective for treating primary Raynaud's phenomenon? As a drug class, calcium channel blockers (CCBs) are minimally effective for reducing the frequency of attacks of primary Raynaud's phenomenon (SOR: A, metaanalysis of RCTs) and reducing the severity of attacks by about 14% (SOR: B, meta-analysis of heterogenous RCTs). Nifedipine may be more effective than other agents in this class (SOR: B, consistent subanalyses within systematic reviews).
Evidence-based practice 20, no. 8 (2017):E1