Angiotensin II deregulates mitochondrial quality control and prevents autophagosome formation in skeletal muscle
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Conclusion: Ang II suppresses autophagy by impairing autophagosome formation, which leads to accumulation of damaged mitochondria and ubiquitinated proteins. Our data strongly suggest that autophagy plays a critical role in Ang II-induced energy imbalance and skeletal muscle wasting, and that it could be a new therapeutic target in wasting disorders such as HF.
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