dc.contributor.author | An, Melissa L | eng |
dc.contributor.author | Smith, Gordon I. | eng |
dc.contributor.author | Klein, Samuel | eng |
dc.contributor.meetingname | Health Sciences Research Day (2017 : University of Missouri) | eng |
dc.date.issued | 2017 | eng |
dc.description | Poster presented at the 2017 Health Sciences Research Day which was organized and sponsored by the University of Missouri School of Medicine Research Council and held on November 9, 2017. | eng |
dc.description.abstract | Obesity is a significant risk factor for cardiometabolic complications, including type 2 diabetes and cardiovascular disease. However, approximately 25% of individuals with obesity are seemingly protected from these complications (Wildman et al. Arch Intern Med, 168, 1617-24, 2008). The purpose of this study was to provide a careful characterization of body composition and metabolic function in people who are: (i) lean and metabolically normal (MNL); (ii) obese and metabolically-normal (MN)); and (iii) obese and metabolically-abnormal (MAO). (Introduction & study aims) Although the glycemic responses of MNL individuals demonstrate a "metabolically healthy" state, more rigorous measures of insulin sensitivity show insulin resistance in this population, demonstrating people with MNO are insulin-resistant with respect to glucose metabolism but are able to maintain normal glycemic control by increased insulin secretion. Adipose tissue distribution is a marker of metabolic health in people with obesity, as greater intra-abdominal adipose tissue volume and intrahepatic triglyceride content are associated with metabolic dysfunction. | eng |
dc.format.extent | 1 poster | eng |
dc.identifier.uri | https://hdl.handle.net/10355/62158 | |
dc.language | English | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Health Sciences Research Day | eng |
dc.rights | OpenAccess. | eng |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. | eng |
dc.title | Differences in glucose control, insulin sensitivity, and body composition between metabolically healthy and unhealthy people with obesity | eng |
dc.type | Poster | eng |