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dc.contributor.authorAmin, Amit P.eng
dc.contributor.authorKennedy, Kevineng
dc.contributor.authorPencina, Michaeleng
dc.contributor.authorBerger, Petereng
dc.contributor.authorPiana, Robert N.eng
dc.contributor.authorLopez, Johneng
dc.contributor.authorKleiman, Nealeng
dc.contributor.authorCohen, David J.eng
dc.contributor.corporatenameUniversity of Missouri (System)eng
dc.contributor.meetingnameMissouri Life Sciences Summit (2010: University of Missouri--Kansas City)eng
dc.date.issued2010-03eng
dc.descriptionComputational Infrastructure and Informatics Poster Sessioneng
dc.description.abstractBackground: Although clopidogrel (CLO) pretreatment benefits PCI patients with acute coronary syndromes, these benefits are less well-established among elective PCI patients—particularly when treated with the direct thrombin inhibitor (DTI), bivalirudin. The effect of timing of CLO pretreatment on ischemic complications in these patients is also unknown. Methods: We used data from the multicenter EVENT registry to assess the association of clopidogrel pretreatment (600 mg 2 hr pre-PCI, 300 mg 6 hrs pre-PCI, or 75 mg/d for 1 week) with PCI-related complications in patients undergoing elective PCI with a DTI as planned antithrombotic. The primary endpoint was the composite of in-hospital death or MI (peak CKMB > 3 x ULN). Results: Between 01/05 and 12/07, 3568 pts underwent elective PCI and 1913 (54%) received DTI as planned anticoagulant (37% diabetics, age 65±10 y). Clopidogrel pre-treatment was used in 923 (48%). There were no differences in in-hospital or 1 year ischemic or bleeding events in relation to clopidogrel pretreatment in both unadjusted and adjusted analyses (see Table). There was a trend toward lower rates of death or MI with earlier pretreatment, however [Odds ratios vs. no pretreatment: >1 week 0.48 (95% CI 0.08 - 2.73); > 6 h OR 0.69 (95% CI 0.11 - 4.45) and 2-6 h OR 0.77 (95% CI 0.18 - 3.31)]. Conclusion: Among unselected patients undergoing elective PCI with DTI as the planned anticoagulant, clopidogrel pretreatment was common, but was not associated with a reduced risk of ischemic complications.eng
dc.identifier.urihttp://hdl.handle.net/10355/6223eng
dc.languageEnglisheng
dc.relation.ispartofAbstracts (Missouri Regional Life Sciences Summit 2010)eng
dc.relation.ispartofcommunityUniversity of Missouri System. Missouri Summits. Missouri Regional Life Sciences Summit 2010eng
dc.subjectacute coronary syndromeseng
dc.subjectischemic complicationseng
dc.subjectdirect thrombin inhibitoreng
dc.subject.lcshCoronary heart diseaseeng
dc.subject.lcshIschemiaeng
dc.titleImpact of Clopidogrel Pretreatment on Ischemic Complications of PCI among Bivalirudin-Treated Patients: Results from the EVENT Registryeng
dc.typePostereng


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