Lupus with Grave's disease : overlap disease vs drug induced lupus : a case report

Abstract

Background: Graves’ disease is one of the T-Cell mediated organ-specific autoimmune thyroid diseases, while SLE is mainly a B-Cell mediated autoantibody regulated systemic autoimmune disease. There is a well-established association of hypothyroidism, autoimmune thyroiditis, and thyroid cancer to systemic lupus erythematosus in age and sex matched controls in diverse populations across the world. The association of SLE and Graves’ disease is extremely rare in adults and has never been reported in the pediatric population. This case report suggests that pediatric patients with thyroid disease or systemic lupus erythematous should be evaluated for one another on the presentation of either.