Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Theses (MU)
    • 2007 Theses (MU)
    • 2007 MU theses - Access restricted to UM
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Theses (MU)
    • 2007 Theses (MU)
    • 2007 MU theses - Access restricted to UM
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Estrogen receptor [alpha] and [beta] knock-out effects on skeletal muscle in mature female and male mice, and aromatase knock-out effects on skeletal muscle in mature male mice

    Ning, Jie
    View/Open
    [PDF] public.pdf (2.621Kb)
    [PDF] short.pdf (59.69Kb)
    [PDF] research.pdf (1.479Mb)
    Date
    2007
    Format
    Thesis
    Metadata
    [+] Show full item record
    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Estrogen regulates skeletal muscle mass and function in female. Estrogen may influence skeletal muscle mass and function during development in males as estrogen receptors (ER) have been identified in both female and male skeletal muscle. Whether estrogen exerts its effects on skeletal muscle through estrogen receptor alpha (ER[alpha]) or beta (ER[beta]) or directly during development is unclear. The main purpose of this study was to determine ER knock-out effects on muscle mass and contractile function in muscle with different fiber types, in mature female and male mice that were either ER[alpha] knock out (ER-/-) or ER[beta]-/- with corresponding wild type (WT) groups as controls. Loss of ER[alpha] results in increased Gast and TA muscle in female mice whereas the muscle functions are not affected, and ER[alpha] also influences female Plan muscle function. In contrast, ER[beta] might not have effects on skeletal muscle in female mice. ER-/- and Ar-/- result in decreased Gast and TA muscle in male mice, suggesting that estrogen/ER[alpha] signaling might directly regulate male muscle growth, whereas the muscle function are not affected. In contrast, ER[beta] might not have any effects on skeletal muscle in male mice.
    URI
    https://hdl.handle.net/10355/6273
    https://doi.org/10.32469/10355/6273
    Degree
    M.S.
    Thesis Department
    Veterinary biomedical sciences (MU)
    Rights
    Access is limited to the campuses of the University of Missouri.
    Collections
    • 2007 MU theses - Access restricted to UM
    • Biomedical Sciences electronic theses and dissertations (MU)

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems