Variable-temperature ¹H-NMR and AB initio study of 5-amino-imidazole-4-carboxamide (AICA): competing paths for amide-H scrambling

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Variable-temperature ¹H-NMR and AB initio study of 5-amino-imidazole-4-carboxamide (AICA): competing paths for amide-H scrambling

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/6281

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dc.contributor.advisor Glaser, Rainer, 1957- en_US
dc.contributor.author Liu, Yang, 1974 Dec. 2- en_US
dc.date.accessioned 2010-03-03T17:56:21Z
dc.date.available 2010-03-03T17:56:21Z
dc.date.issued 2008 en_US
dc.date.submitted 2008 Fall en_US
dc.identifier.other LiuY-110309-T11746 en_US
dc.identifier.uri http://hdl.handle.net/10355/6281
dc.description Title from PDF of title page (University of Missouri--Columbia, viewed on Feb. 18, 2010). en_US
dc.description The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. en_US
dc.description Dr. Rainer Glaser, Thesis Supervisor. en_US
dc.description Includes bibliographical references. en_US
dc.description M.S. University of Missouri--Columbia 2008. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Chemistry. en_US
dc.description.abstract 5(4)-aminoimidazole-4(5)-carboxamide (AICA and TAICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular. Biotic nucleobase synthesis has been studied in great detail and its chemistry and biochemistry are understood very well. In contrast, hypotheses regarding prebiotic nucleobase syntheses remain controversial. While such studies focused on aqueous solution chemistry for half a century, planetary nucleobase syntheses in frozen solids (ice) and other extreme environments have been explored in the past two decades. Spectacular advances in observational astronomy and the evolving knowledge about the chemistry and physics of the interstellar medium (ISM) suggest new options and the very possibility of prebiotic nucleobase synthesis in the cold ISM. The discourse about prebiotic chemistry in interstellar space relies on observational astronomy. Hence, precise knowledge is required about the spectroscopic properties of presumed intermediates together with knowledge of their structural preferences and their isomerization dynamics. Here, we report on the structure and dynamics of AICA in a variety of solvents and the gas phase. The interplay between CC- and CN- rotations are discussed as well. en_US
dc.format.extent vii, 63 pages en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2008 Freely available theses (MU) en_US
dc.subject Prebiotic nucleobase synthesis. en_US
dc.subject Prebiotic nucleobase synthesis en_US
dc.subject.lcsh Purines -- Synthesis en_US
dc.subject.lcsh Cosmochemistry en_US
dc.title Variable-temperature ¹H-NMR and AB initio study of 5-amino-imidazole-4-carboxamide (AICA): competing paths for amide-H scrambling en_US
dc.type Thesis en_US
thesis.degree.discipline Chemistry en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name M.S. en_US
thesis.degree.level Masters en_US
dc.identifier.oclc 535480275 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2008 Theses


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