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dc.contributor.advisorGlaser, Rainer, 1957-eng
dc.contributor.authorLiu, Yang, 1974 Dec. 2-eng
dc.date.issued2008eng
dc.date.submitted2008 Falleng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on Feb. 18, 2010).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionDr. Rainer Glaser, Thesis Supervisor.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionM.S. University of Missouri--Columbia 2008.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Chemistry.eng
dc.description.abstract5(4)-aminoimidazole-4(5)-carboxamide (AICA and TAICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular. Biotic nucleobase synthesis has been studied in great detail and its chemistry and biochemistry are understood very well. In contrast, hypotheses regarding prebiotic nucleobase syntheses remain controversial. While such studies focused on aqueous solution chemistry for half a century, planetary nucleobase syntheses in frozen solids (ice) and other extreme environments have been explored in the past two decades. Spectacular advances in observational astronomy and the evolving knowledge about the chemistry and physics of the interstellar medium (ISM) suggest new options and the very possibility of prebiotic nucleobase synthesis in the cold ISM. The discourse about prebiotic chemistry in interstellar space relies on observational astronomy. Hence, precise knowledge is required about the spectroscopic properties of presumed intermediates together with knowledge of their structural preferences and their isomerization dynamics. Here, we report on the structure and dynamics of AICA in a variety of solvents and the gas phase. The interplay between CC- and CN- rotations are discussed as well.eng
dc.format.extentvii, 63 pageseng
dc.identifier.oclc535480275eng
dc.identifier.otherLiuY-110309-T11746eng
dc.identifier.urihttp://hdl.handle.net/10355/6281eng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2008 Freely available theses (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2008 Theseseng
dc.subjectPrebiotic nucleobase synthesis.eng
dc.subjectPrebiotic nucleobase synthesiseng
dc.subject.lcshPurines -- Synthesiseng
dc.subject.lcshCosmochemistryeng
dc.titleVariable-temperature ¹H-NMR and AB initio study of 5-amino-imidazole-4-carboxamide (AICA): competing paths for amide-H scramblingeng
dc.typeThesiseng
thesis.degree.disciplineChemistry (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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