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    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Theses (MU)
    • 2008 Theses (MU)
    • 2008 MU theses - Access restricted to MU
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    Investigative study of long-term packaging effects and donor characteristics on acellular dermis scaffolds

    White, Amanda Kay
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    [PDF] research.pdf (5.499Mb)
    Date
    2008
    Format
    Thesis
    Metadata
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    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Acellular tissue sources have become progressively popular for a variety of tissue engineering and medical applications, such as soft tissue augmentation, skin and vascular grafts, engineered scaffolds, and hernia repair materials. Before tissue sources can be utilized commercially for these practices they usually are decellularized, i.e., have all cellular and nuclear material removed from the extracellular matrix (ECM), and then they are packaged in a convenient, sterile manner for the medical community. While the decellularization techniques have been extensively researched, little is known about the effects of storage or the variability of donor characteristics on the decellularized ECM scaffold. In these studies, acellular dermal grafts stored in ethanol and DI water were analyzed, along with fresh and processed grafts of varying donor characteristics. Dermal grafts from three human donors were subject to varying storage times (t=7 days, 14 days, 30 days, 60 days, and 90 days) to assess the degree of physicochemical changes in the ECM scaffold. Fresh and processed grafts of ten donors with varying backgrounds were used to assess the variability of donor characteristics. Differential scanning calorimetry (DSC), FT-IR spectroscopy, collagenase assay, and tensile testing were utilized to determine ECM variation and physicochemical changes based on storage times and donor variability.
    URI
    https://doi.org/10.32469/10355/6292
    https://hdl.handle.net/10355/6292
    Degree
    M.S.
    Thesis Department
    Biological engineering (MU)
    Rights
    Access is limited to the campus of the University of Missouri--Columbia.
    Collections
    • 2008 MU theses - Access restricted to MU
    • Biological Engineering electronic theses and dissertations - CAFNR (MU)
    • Biological Engineering electronic theses and dissertations - Engineering (MU)

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