Browsing 2018 UMKC Dissertations - Freely Available Online by Thesis Department "Cell Biology and Biophysics (UMKC)"
Now showing items 1-4 of 4
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Effect of TIMBD on Neurotoxicity Associated with HIV-1 Gp120 and Tat
(University of Missouri -- Kansas City, 2018)Human Immunodeficiency Virus (HIV)-associated neurocognitive disorder (HAND) is one of the undermining disorders that affects majority of HIV infected patients. Patients with HAND suffer from both cognitive and motor ... -
Identification of Novel Regulatory Genes in Acetaminophen Induced Hepatocyte Toxicity by a Genome-Wide CRISPR/Cas9 Screen
(University of Missouri -- Kansas City, 2018)Acetaminophen (APAP) is a commonly used analgesic responsible for over 56,000 overdose-related emergency room visits annually. A long asymptomatic period and limited treatment options result in a high rate of liver ... -
Mechanism of Action of Nicotinamide Phosphoribosyltransferase Mediated Signaling in Oxidative Stress
(University of Missouri -- Kansas City, 2018)Worldwide there are an estimated 1 billion people that are affected by a form of neurodegenerative disease. The most common forms of neurodegenerative disease are Alzheimer’s disease and Parkinson’s disease, along ... -
Structure/Function Analysis of Type IIa Receptor Tyrosine Phosphatases on Drosophila Muscle Integrity
(University of Missouri -- Kansas City, 2018)The Lar-family of receptor protein tyrosine phosphatases (RPTPs); including Lar, RPTPσ and RPTPδ, are utilized in signal transduction pathways during neural development. Fundamentally, the processes of axon guidance ...