Browsing 2018 UMKC Dissertations - Freely Available Online by Thesis Department "Pharmaceutical Sciences (UMKC)"
Now showing items 1-9 of 9
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Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
(University of Missouri -- Kansas City, 2018)The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce ... -
Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
(University of Missouri -- Kansas City, 2018)The objective of this dissertation is to develop a protein-based siRNA nanocomplex for the treatment of alcoholic liver fibrosis. Our laboratory recently discovered that silencing the poly (rC) binding protein 2 (PCBP2) ... -
Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis
(University of Missouri -- Kansas City, 2018)The objective of this dissertation is to develop various systems to deliver small interfering RNA (siRNA) for the treatment of triple negative breast cancer (TNBC) and liver fibrosis. siRNAs targeting vascular endothelial ... -
Engineering of Human Acid Phosphatase Enzyme Sensitive Nanomedicine for HIV/AIDS Prevention by Topical Route
(University of Missouri -- Kansas City, 2018)This study is divided into two aims. Aim #1 focuses on the development and characterization of tenofovir (TFV) loaded a stimuli sensitive nanomedicine against male to female HIV/AIDS infection. Aim #2 focus on the ... -
Establishing Metronidazole as a Novel Biomarker of CYP2A6 Activity
(University of Missouri -- Kansas City, 2018)CYP2A6 is a polymorphically expressed enzyme with variation associated with smoking behavior, cessation success, lung cancer risk, and differential drug exposure to numerous medications including anti-infectious and ... -
Evaluation of the Anti-Fibrotic Activity of PCBP2 siRNA in Primary Hepatic Stellate Cells and Discovery of Anti-PD-L1 Peptide and Nanobody for Immunotherapy
(University of Missouri -- Kansas City, 2018)There are two major research objectives in this dissertation. Our laboratory recently discovered a small interfering RNA (siRNA) that silences the poly (rC) binding protein 2 (PCBP2) gene. It is hypothesized that silencing ... -
Novel Prodrugs and Self-Assembling Nanocarriers to Improve Drug Delivery
(University of Missouri -- Kansas City, 2018)PART I: DIPEPTIDE PRODRUG APPROACH TO IMPROVE INTESTINAL ABSORPTION OF LOPINAVIR Lopinavir (LPV), a highly potent second-generation HIV-1 protease inhibitor, is currently indicated in HIV-1 infection. However, poor ... -
Preparation of Pentablock Nanomicellar Formulations for Prostate Cancer Drug Delivery Systems
(University of Missouri -- Kansas City, 2018)This study is divided into three specific aims. Specific aim #1 focused on synthesis of pentablock co-polymer using monomers of L-lactide, ε-caprolactone and ethylene-glycol with varied molecular weights, (ii) ... -
Role of Redox-Active Trace Metal (RATM) Oxidants in the Regulation of Toll-Like Receptor 4 (TLR4) Signaling-Mediated Inflammatory Phenotype in Synovial Fibroblasts
(University of Missouri -- Kansas City, 2018)While the involvement of oxidant stress in rheumatoid arthritis (RA) has been suspected, the role of redox-active trace metals (RATM) as exogenous pro-oxidants in the pathogenesis of RA has not yet been investigated. ...