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dc.contributor.advisorKing, Gavin M., 1975-eng
dc.contributor.authorMatin,Tina Rezaieeng
dc.date.issued2017eng
dc.date.submitted2017 Springeng
dc.descriptionField of study: Physics.eng
dc.descriptionDr. Gavin King, Dissertation Supervisor.eng
dc.description"May 2017."eng
dc.description.abstractDespite the utmost importance of protein- lipid interactions in cellular activity, due to technical difficulties, this class of interactions has not been understood mechanistically. Obtaining a more complete understanding of these interactions would, for example, aid the design of more compatible and effective medicine to target specific cells. We developed a physical technique to study such interactions and investigated the interactions between small portions of a model protein with different types of membrane. We were able to detect physical interaction differences between the two at the single-molecule level. This technique is generalizable to study other small molecule-membrane interactions and helps scientists to have a better understanding of the transport of energy, nutrition and waste in and out of the cells. The machine that has been used in our investigations is a mechanical microscope called an AFM (atomic Force Microscope). In addition to making a topographical images, this tool enables us to pick up small molecules in a controlled and precise manner.eng
dc.description.bibrefIncludes bibliographical references (pages 97-108).eng
dc.format.extent1 online resource (xi, 140 pages) : illustrations (chiefly color)eng
dc.identifier.merlinb129598276eng
dc.identifier.oclc1101670067eng
dc.identifier.urihttps://hdl.handle.net/10355/63869
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccesseng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.eng
dc.titleInvestigating peptide-lipid interactions at single molecule leveleng
dc.typeThesiseng
thesis.degree.disciplinePhysics (MU)eng
thesis.degree.grantor[University of Missouri--Columbia]eng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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