Treatment Options for urinary tract infections caused by extended-spectrum B-lactamase-producing Escherichia coli and Klebsiella pneumoniae
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Increased utilization of antibiotics has contributed to greater resistance among pathogenic bacteria. The prevalence of such organisms has created challenges for practitioners treating bacterial infections. One of the most frequently encountered infections in both inpatient and outpatient settings is urinary tract infections (UTIs). is the most commonly isolated uropathogen. Both and are capable of producing extended-spectrum B-lactamases (ESBL) which result in resistance to many antibiotics that are typically used in the treatment of UTIs. An analysis of inpatient urinary isolates in the United States found rates of ESBL-producing (ESBL-EC) and (ESBL-KP) to be 6.8[percent] and 10.3[percent], respectively.