11beta-Hydroxysteroid dehydrogenase activity in adipose tissue [abstract]

MOspace/Manakin Repository

Breadcrumbs Navigation

11beta-Hydroxysteroid dehydrogenase activity in adipose tissue [abstract]

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/647

[+] show full item record


Title: 11beta-Hydroxysteroid dehydrogenase activity in adipose tissue [abstract]
Author: Lehenbauer, Jessica
Contributor: University of Missouri-Columbia. Office of Undergraduate Research
Keywords: obesity
adipose stromal cells
adipocytes
11beta-hydroxysteroid dehydrogenase(11B-HSD1)
Date: 2004
Publisher: University of Missouri--Columbia. Office of Undergraduate Research
Abstract: Obesity is a major health and social problem, which has been linked to hypertension, cardiovascular disease, diabetes mellitus, and malignancies. Obesity occurs as a result of hypertrophy of existing adipocytes, or an increase in the differentiation of adipose stromal cells into mature adipocytes. Recent studies have shown an obesity-associated increase in the activity of type 1 11beta-hydroxysteroid dehydrogenase(11B-HSD1), an enzyme which generates the glucocorticoid, cortisol from corticosterone via 11-ketoreductase reaction. 11B-HSD1 is a bi-directional enzyme that also possess 11B-dehydrogenase activity, though in vivo it acts primarily as an 11-ketoreductase. Glucocorticoids play an important role in regulating both adipose tissue function and distribution as well as promoting the differentiation of preadipocytes into mature adipocytes. The elevation in 11B-HSD1 11-Ketoreductase activity has been shown to be particularly important in omental adipose tissue.
URI: http://hdl.handle.net/10355/647

This item appears in the following Collection(s)

[+] show full item record