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dc.contributor.authorLehenbauer, Jessicaen
dc.contributor.corporatenameUniversity of Missouri-Columbia. Office of Undergraduate Researchen
dc.contributor.meetingnameUndergraduate Research and Creative Achievements Forum (2004 : University of Missouri--Columbia)en
dc.date.issued2004eng
dc.descriptionAbstract only availableen
dc.descriptionFaculty Mentor: Dr. Frank Booth, Biochemistryen
dc.description.abstractObesity is a major health and social problem, which has been linked to hypertension, cardiovascular disease, diabetes mellitus, and malignancies. Obesity occurs as a result of hypertrophy of existing adipocytes, or an increase in the differentiation of adipose stromal cells into mature adipocytes. Recent studies have shown an obesity-associated increase in the activity of type 1 11beta-hydroxysteroid dehydrogenase(11B-HSD1), an enzyme which generates the glucocorticoid, cortisol from corticosterone via 11-ketoreductase reaction. 11B-HSD1 is a bi-directional enzyme that also possess 11B-dehydrogenase activity, though in vivo it acts primarily as an 11-ketoreductase. Glucocorticoids play an important role in regulating both adipose tissue function and distribution as well as promoting the differentiation of preadipocytes into mature adipocytes. The elevation in 11B-HSD1 11-Ketoreductase activity has been shown to be particularly important in omental adipose tissue.en
dc.identifier.urihttp://hdl.handle.net/10355/647en
dc.publisherUniversity of Missouri--Columbia. Office of Undergraduate Researchen
dc.relation.ispartof2004 Undergraduate Research and Creative Achievements Forum (MU)en
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Office of Undergraduate Research. Undergraduate Research and Creative Achievements Forum
dc.source.urihttp://undergradresearch.missouri.edu/forums-conferences/abstracts/abstract-detail.php?abstractid=117en
dc.subjectobesityen
dc.subjectadipose stromal cellsen
dc.subjectadipocytesen
dc.subject11beta-hydroxysteroid dehydrogenase(11B-HSD1)en
dc.title11beta-Hydroxysteroid dehydrogenase activity in adipose tissue [abstract]en
dc.typeAbstracten


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