11beta-Hydroxysteroid dehydrogenase activity in adipose tissue [abstract]

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11beta-Hydroxysteroid dehydrogenase activity in adipose tissue [abstract]

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/647

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dc.contributor.author Lehenbauer, Jessica en
dc.date.accessioned 2009-03-13T18:29:58Z en
dc.date.available 2009-03-13T18:29:58Z en
dc.date.issued 2004 en
dc.identifier.uri http://hdl.handle.net/10355/647 en
dc.description Abstract only available en
dc.description Faculty Mentor: Dr. Frank Booth, Biochemistry en
dc.description.abstract Obesity is a major health and social problem, which has been linked to hypertension, cardiovascular disease, diabetes mellitus, and malignancies. Obesity occurs as a result of hypertrophy of existing adipocytes, or an increase in the differentiation of adipose stromal cells into mature adipocytes. Recent studies have shown an obesity-associated increase in the activity of type 1 11beta-hydroxysteroid dehydrogenase(11B-HSD1), an enzyme which generates the glucocorticoid, cortisol from corticosterone via 11-ketoreductase reaction. 11B-HSD1 is a bi-directional enzyme that also possess 11B-dehydrogenase activity, though in vivo it acts primarily as an 11-ketoreductase. Glucocorticoids play an important role in regulating both adipose tissue function and distribution as well as promoting the differentiation of preadipocytes into mature adipocytes. The elevation in 11B-HSD1 11-Ketoreductase activity has been shown to be particularly important in omental adipose tissue. en
dc.language.iso en_US en
dc.publisher University of Missouri--Columbia. Office of Undergraduate Research en
dc.relation.ispartof 2004 Undergraduate Research and Creative Achievements Forum (MU) en
dc.source.uri http://undergradresearch.missouri.edu/forums-conferences/abstracts/abstract-detail.php?abstractid=117 en
dc.subject obesity en
dc.subject adipose stromal cells en
dc.subject adipocytes en
dc.subject 11beta-hydroxysteroid dehydrogenase(11B-HSD1) en
dc.title 11beta-Hydroxysteroid dehydrogenase activity in adipose tissue [abstract] en
dc.type Abstract en
dc.contributor.meetingname Undergraduate Research and Creative Achievements Forum (2004 : University of Missouri--Columbia) en
dc.contributor.corporatename University of Missouri-Columbia. Office of Undergraduate Research en
dc.relation.ispartofcommunity University of Missouri-Columbia. Office of Undergraduate Research. Undergraduate Research and Creative Achievements Forum


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