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dc.contributor.advisorJiJi, Ren�e Deniseeng
dc.contributor.authorZare, Anahitaeng
dc.date.issued2017eng
dc.date.submitted2017 Summereng
dc.descriptionField of study: Chemistry.eng
dc.descriptionDr. Renee D. JiJi, Dissertation Supervisor.eng
dc.descriptionIncludes vita.eng
dc.description"July 2017."eng
dc.description.abstractMembrane protein function and structure determination is vital for pharmaceutical development and disease prevention. Despite the various methods of protein structure elucidation in use, a need still exists for techniques that are of adequate resolution, rapid, inexpensive, and compatible with the membrane environment of these proteins. Deep UV resonance Raman (dUVRR) spectroscopy is an emerging structurally sensitive spectroscopic technique for analyzing membrane protein structure. The backbone amide modes are resonance enhanced in dUVRR spectra while the membrane's lipid features are not, resulting in strong membrane protein spectral features in near native environments. In order to better define dUVRR spectral features of membrane proteins, a series of model helical peptides, poly(LA)7, were designed. By substituting select residues of the transmembrane region of poly(LA)7, the propensity of helical structure within a membrane has also been studied. Using these model membrane peptides in increasingly dehydrated environments (aqueous, surfactant, and bilayer), hydration depended changes in the spectra are characterized.eng
dc.description.bibrefIncludes bibliographical references.eng
dc.format.extent1 online resource (x, 109 pages) : illustrations (chiefly color)eng
dc.identifier.merlinb129185528eng
dc.identifier.oclc1099182665eng
dc.identifier.urihttps://hdl.handle.net/10355/65447
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.eng
dc.titleDeep UV resonance Raman spectral properties of alpha helical membrane proteinseng
dc.typeThesiseng
thesis.degree.disciplineChemistry (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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