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The effect of laryngeal nerve transection on swallowing function in a mouse model
(University of Missouri--Columbia, 2017)
Dysphagia is a common postoperative complication of cervical and thoracic surgical procedures, presumably caused by iatrogenic laryngeal nerve injury. It is unknown which laryngeal nerve contributes most to dysphagia and ...
Standardizing a freely-behaving canine videofluoroscopic swallow study protocol to investigate dysphagia in primary aging and neurological diseases
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The goal of this study was to establish a freely-behaving videofluoroscopic swallow study protocol (VFSS) for dogs that permits identification of ...
Characterization of dysphagia onset in a mouse model of amyotrophic lateral sclerosis (ALS
(University of Missouri--Columbia, 2017)
The primary goal of this study was to characterize dysphagia onset and progression in the low copy number SOD1-G93A (LCN-SOD1) mouse model of ALS. A secondary goal was to determine the effect of serial radiation exposure ...
Effects of menthol on swallowing function in a mouse model of presbyphagia
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The goal of this study was to characterize the progression of presbyphagia in our recently established mouse model and investigate the treatment effect ...
Videofluoroscopic characterization of dysphagia in the low copy number SOD1-G93A transgenic mouse model of ALS
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The goal of this study was to determine if the SOD1-G93A low copy number mouse model of ALS is a suitable model for studying dysphagia (i.e., swallowing ...
Noninvasive clinical tools to aid in early detection and monitoring of dysphagia in ALS : translating findings from mice to humans
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Previous work in our lab identified lingual dysfunction (i.e., slow lick rate) as the earliest clinical sign of dysphagia in SOD1-G93A transgenic mice, ...
Identification of dysphagia in a transgenic mouse model of amyotrophic lateral sclerosis
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Previous work in our lab has established the SOD1-G93A transgenic mouse as a suitable model for dysphagia (swallowing impairment) in amyotrophic lateral ...
Using the laryngeal adductor reflex to investigate swallowing
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The goal of this study was to develop a protocol to facilitate identification and quantification of the pathological components of the complex neural ...
Videofluoroscopic characterization of swallowing impairment in mouse models of amyotrophic lateral sclerosis and advanced aging
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The goal of this study was to establish a videofluoroscopic swallow study (VFSS) protocol for mice that permits identification of translational biomarkers ...
Characterization of dysphagia in a canine model of late infantile neuronal ceroid lipofuscinosis
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Late Infantile Neuronal Ceroid Lipofuscinosis, also known as CLN2, is the most common form of Batten disease in children. Nearly all children with CLN2 ...
Investigating canine degenerative myelopathy as a disease model of amyotrophic lateral sclerosis for histopathological evidence of dysphagia
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Unspecified swallowing impairment (dysphagia) was recently reported in dogs with degenerative myelopathy (DM), a proposed disease model of amyotrophic ...