Controlling the kinematics of the left ventricle to treat resistant hypertension
The intention of this thesis is to present a novel controller design that eliminates hypertension in patients who suffer from resistant hypertension. The controller is designed by first translating the functionality of the left ventricle (LV) from a biological system to a system of dynamic equations, which is accomplished by defining pressure-rise-rate equations for the LV and aorta. The result is a dynamic model completely describing these pressures in terms of cardiovascular parameters associated with the LV. Using this model, the LV volume is controlled by implementing a first-order dynamic model for the LV. This produces a controller design capable of reducing systolic and diastolic aortic pressures to values that the physician desires; moreover, by defining hypertensive pressures within the cardiovascular system, the controller presented in this thesis demonstrates the effectiveness that controlling LV volume has in reducing aortic pressures to desired values.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.