This collection contains the posters presented at the Missouri Regional Life Sciences Summit 2010. Please enter text in the search box above or click on one of the browse options to explore this collection.

Recent Submissions

  • Small Business Support for Youth Physical Activity Opportunities 

    Suminski, Richard R.; Tota, Tonya; Dinius, David (2010-03)
    Background: Increasing the number of youth physical activity opportunities (YPAO) (e.g., programs) may be a promising approach for encouraging physically active lifestyles among youth. To do this effectively, we need ...
  • Toxicty of a Serotonin-derived Neuromelanin 

    Miller, Elizabeth D.; Fibuch, Eugene; Seidler, N. W. (2010)
    Introduction: POCD (Postoperative Cognitive Dysfunction) is associated with increased mortality and disability and may develop as a consequence of lipid peroxidative byproducts (i.e. acrolein), which accumulate with aging. ...
  • Effects of Isoflurane on Plasma-Membrane Calcium ATPase 

    Monaco, J.; Seidler, N. W.; Fibuch, Eugene; Zaidi, A. (2010-03)
    Introduction: Plasma membrane Ca2+-ATPase (PMCA) is a transmembrane enzymatic protein present in human neurons, myocytes, and RBCs which plays a role in controlling cellular Ca2+ levels by regulating intracellular ATP. ...
  • Regulation of Phosphorylation of Dopamine D3 Receptors in Mouse Striatal Neurons in vivo 

    Rivera, D.; Mao, Li-Min; Fibuch, Eugene; Wang, John Q. (2010-03)
    Introduction: Dopamine D3 receptors (D3Rs) are G-protein-coupled receptors. These D3Rs inhibit adenylyl cyclase and the downstream formation of cAMP. Due to their preferential expression in the mesolimbic areas, especially ...
  • Amphetamine Alters Group I mGluR Expression in the Rat Striatum and Medial Prefrontal Cortex 

    Shaffer, C. B.; Mao, Li-Min; Fibuch, Eugene; Wang, John Q. (2010-03)
    Introduction: Group I metabotropic glutamate receptors (mGluR1/mGluR5 subtypes) and their key scaffolding protein Homer1b/c are densely expressed in the striatum. These receptors are believed to play important roles in ...
  • Amphetamine Alters Acid-Sensing Ion Channel Expression in the Rat Striatum 

    Suman, A.; Mao, Li-Min; Fibuch, Eugene; Wang, John Q. (2010-03)
    Introduction: The acid-sensing ion channel (ASIC) is specifically activated by a drop in the extracellular pH level. These channels are widely expressed in mammalian brains and actively modulate synaptic transmission and ...
  • Continuous Monitoring of Tissue Regrowth Using Optical Biosensors 

    Bhagwat, Prajakta; Henthorn, David B.; Kim, Chang-Soo (2010-03)
    The engineered regeneration of bone is a significant challenge being undertaken to treat conditions such as traumatic casualties, bone cancer, osteoporosis, etc. Advances in regrowth of hard tissue may potentially lead to ...
  • A Study of RO5217790 (HPV Targeted Immunotherapy) in Patients With High Grade Cervical Intraepithelial Neoplasia Associated With High Risk HPV Infection 

    Harper, Diane Medved; Harris, George D.; Shaffer, Todd D.; Gabriel, Michelle; Hoffmann-LaRoche; Santee, Jennifer (2010-03)
    This is a randomized, double blind, placebo controlled, parallel group multicenter study in women with biopsy confirmed Grade 2 or Grade 3 cervical intraepithelial neoplasia (CIN). Two hundred patients will be enrolled and ...
  • 3q26 Amplification is Rarely Present in Women Whose LSIL Cytology does not Represent CIN 2+ Disease 

    Harper, Diane Medved; Lankachandra, K. M.; Wall, Jeffrey; Jalali, G. R.; Kershnar, E.; Harris, George D.; Bonham, Aaron James; Shaffer, Todd D. (2010-03)
    Objective: 10-17% of women with LSIL cytology truly have CIN 2+ disease at colposcopically directed biopsy and 20% of the CIN 2+ lesions derive from women with LSIL cytology. No molecular marker has yet been able to triage ...
  • Development of a Telemetry Unit for Wireless Monitoring of Bone Strain 

    Moiz, Fahad; Huang, Qian; Leon-Salas, Walter D. (Walter Daniel); Johnson, Mark L. (Mark Louis) (2010-03)
    A telemetry unit designed to monitor strain in bones is presented. This unit allows studying the relationship between bone load and bone mass in scenarios that were not possible with current setup. The current measuring ...
  • Are There Leaks in Your Product Pipeline? 

    Sebaugh, Jeanne L.; Hearne, Leonard B.; Flournoy, Nancy, 1947- (2010-03)
    Successful businesses move new products through the development pipeline swiftly and efficiently. An integral part of this process is the research design and execution. The field of statistics can provide knowledge and ...
  • Unprecedented protection of the retina from glaucoma-induced nerve damage by topical administration of a novel prodrug 

    Koulen, Peter; Prokai, Laszlo, 1958-; Xin, Hua; Nguyen, Vin; Prokai-Tatrai, Katalin (2010-03)
    The preclinical development of a prodrug-based site-specific delivery strategy that allows for targeting a potent small-molecule neuroprotectant into the eye, and with preference to the retina, after topical administration ...
  • Turbo Mohs for Basal Cell Carcinoma Skin Cancer 

    Stoecker, William V. (2010-03)
    Mohs skin cancer surgery is also known as microscopically-controlled surgery because at each stage in the Mohs procedure, a new layer of tissue is obtained surgically and frozen sections made, allowing a microscopic reading ...
  • Targeting Tick Borne Diseases 

    Stich, Roger W. (2010-03)
    Ticks transmit the majority of vector-borne diseases of human beings in the USA and of domestic animals worldwide. Among these, tick-borne rickettsial pathogens cause at least four important tick-borne zoonoses in the USA, ...
  • Guided-mode resonance biochip system for early detection of ovarian cancer 

    Koulen, Peter; Wawro, Debra (2010-03)
    A high-accuracy, sensor system has been developed that provides near-instantaneous detection of biomarker proteins as indicators of ovarian serous papillary carcinoma. Based upon photonic guided-mode resonance technology, ...
  • Multi-disciplinary Collaborations in Measurement of Human Motion 

    Guess, Trent M.; Derakhshani, Reza; King, Gregory W.; Leon-Salas, Walter D. (Walter Daniel) (2010-03)
    Bioengineering is a broad and rapidly-growing discipline defined as the application of engineering principles to biological systems. Although bioengineering is diverse in nature, the study of human movement is common to ...
  • Tao3 mediates a phenotypic switch between amoeba-adapted and mammalian-adapted forms of Cryptococcus neoformans 

    Magditch, Denise A.; Idnurm, Alexander (2010-03)
    Many microbes are capable of changing phenotypes more frequently than due to basal mutation rates alone, and this ability is coupled to pathogenesis. The human pathogenic yeast Cryptococcus neoformans is found in the ...
  • An Intelligent Online System for Enhanced Recruitment of Patients for Clinical Research 

    Lee, Yugyung, 1960-; Dinakarpandian, Deendayal; Wubbenhorst, John; Owens, Dennis; Dinakarpandian, Deendayal; Mathur, Sachin; Katakam, Nikhilesh, 1987-; Krishnamoorthy, Saranya (2010-03)
    The recruitment and retention of subjects for clinical research has been identified as one of the bottlenecks in the development of new drugs and treatments by the healthcare industry. The Kansas City Area Life Sciences ...
  • Shelter Dog Behavior Improvement: Dog Walking as Enrichment 

    Johnson, Rebecca A. (Rebecca Ann); McKenney, Charlotte; McCune, Sandra (2010-03)
    Background: Several million dogs are euthanized in animal shelters annually after multiple relinquishment reasons (Scarlett, 2002; Salman, 1998; New, 2000 & Kass, 2001). Gains in pet adoptions are happening via shelter ...
  • Effect of Radius on Load Distribution within Mouse Forearm Structure: Experimental and Numerical Analyses 

    Lu, Yunkai; Thiagarajan, Ganesh, 1963-; Johnson, Mark L. (Mark Louis) (2010-03)
    It has been hypothesized that osteocytes are stimulated by local strain distribution within the bone subjected to mechanical loadings. This collaborative research project between bone biologists and mechanical engineers ...

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