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Cloning & Transgenic Swine for Medical and Agricultural Uses at MU
(2010-03)
The pig is an important component of the world's food supply. As of December 1, 2009 the hog inventory in the United States of America was 65 million head. The United States is the world's third largest producer and second ...
Flexible Carbon Nanotube-Based Strain Gage Sensors
(2010-03)
Aging brings about dramatic changes in the skeleton and other organ systems. Major skeletal diseases associated with aging include osteoporosis and attendant fractures (hip, spine and wrist or Collies) and osteoarthritis ...
Swab Test Using ELISA Technique for Diagnosis of Brown Recluse Bites
(2010-03)
Envenomations by the brown recluse spider, Loxosceles reclusa, are a significant source of morbidity and occasional mortality in endemic regions of the United States, and misdiagnoses are common. A survey of physicians ...
Photoacoustic Detection of Circulating Prostate, Breast and Pancreatic Cancer cells using targeted Gold Nanoparticles: Implications of Green Nanotechnology in Molecular Imaging
(2010-02)
Circulating tumor cells are hallmarks of metastasis cancer. The presence of circulating tumor cells in blood stream correlates with the severity of disease. Photoacoustic imaging (PA) of tumor cells is an attractive technique ...
Neutersol® from Laboratory to Market--Lessons Learned
(2010-02)
Even though there is worldwide human and pet overpopulation, it is difficult to secure enough research funding to support development of male contraceptive medicines and devices. The reality is that research funding in ...
Interdisciplinary Approach to Examine the Effects of Lifestyle Modifications on Nonalcoholic Fatty Liver Disease
(2010)
A critical complication of the obesity epidemic experienced in Westernized societies is nonalcoholic fatty liver disease (NAFLD). NAFLD, fatty liver not due to alcohol consumption, is the most common chronic liver disease ...
Use of Aggregation Prediction in Protein Formulations for Excipient Design
(2010-03)
A major concern in the development therapeutic protein formulations is protein aggregation. Proteins can interact to form bound groups of protein molecules or aggregates. Aggregates in protein formulations reduce effectiveness ...
Hyperthermia Induces Functional and Molecular Modifications in Cardiac, Smooth and Skeletal Muscle Cells
(2010-03)
Hyperthermia is used for the treatment of a number of diseases, including muscle injuries, inflammations, tendinitis, and osteoarticular disorder. More recently, hyperthermia has been used as an adjuvant in cancer treatment. ...
Patterns and predictors of fast food consumption after acute myocardial infarction
(2010-03)
Background: Fast food is affordable and convenient, yet high in calories, saturated fat and sodium. The prevalence of fast food intake at the time of acute myocardial infarction (AMI) and patterns of fast food intake in ...
Prevalence, Correlates, and Inter-hospital Variation of Early Outpatient Follow-up After Acute Myocardial Infarction
(2010-03)
Background: Early outpatient follow-up (EFU) after acute myocardial infarction (AMI) is strongly endorsed in guidelines and has been emphasized nationally as a means to improve transitions of care, medication adherence ...
MU Biodesign and Innovation Program
(2010-02)
The MU Biodesign and Innovation Program (MUBIP) centers its efforts off two tiers: (1) formal educational training through a biodesign and innovation fellowship and (2) interdisciplinary faculty collaboration. The Department ...
Walk A Hound, Lose A Pound, & Stay Fit for Seniors
(2010)
Background: Obesity rates in older adults are linked with the national problem of limited physical activity (PA), resulting in chronic illness. Obesity-related illness and functional loss require innovative interventions. ...
Why Humans Do What They Do: Interdisciplinary Research on Realistic Decision Making
(2010)
MU has enormous potential to be the site of path-breaking interdisciplinary research on the topic of realistic decision making. Not only is this research a basic component of human life science, it also has clear application ...
Public-Private Collaborations to Promote Adult Literacy
(2010-03)
Health literacy entered health care discourse when the 2003 National Adult Literacy Survey revealed that nearly half the US adult population has serious deficiencies in reading & computational skills, with one in four ...
Porcine induced pluripotent stem cells (piPSC) for expanding the use of swine in biomedical research
(2010-03)
Our goal is to create porcine pluripotent stem cells, i.e. ones capable of differentiating into all cell types of the body that can expand the use of swine as a biomedical model for studying human disease. It is well ...
Effects of Isoflurane on Plasma-Membrane Calcium ATPase
(2010-03)
Introduction: Plasma membrane Ca2+-ATPase (PMCA) is a transmembrane enzymatic protein present in human neurons, myocytes, and RBCs which plays a role in controlling cellular Ca2+ levels by regulating intracellular ATP. ...
Regulation of Phosphorylation of Dopamine D3 Receptors in Mouse Striatal Neurons in vivo
(2010-03)
Introduction: Dopamine D3 receptors (D3Rs) are G-protein-coupled receptors. These D3Rs inhibit adenylyl cyclase and the downstream formation of cAMP. Due to their preferential expression in the mesolimbic areas, especially ...
Amphetamine Alters Acid-Sensing Ion Channel Expression in the Rat Striatum
(2010-03)
Introduction: The acid-sensing ion channel (ASIC) is specifically activated by a drop in the extracellular pH level. These channels are widely expressed in mammalian brains and actively modulate synaptic transmission and ...
Amphetamine Alters Group I mGluR Expression in the Rat Striatum and Medial Prefrontal Cortex
(2010-03)
Introduction: Group I metabotropic glutamate receptors (mGluR1/mGluR5 subtypes) and their key scaffolding protein Homer1b/c are densely expressed in the striatum. These receptors are believed to play important roles in ...
Toxicty of a Serotonin-derived Neuromelanin
(2010)
Introduction: POCD (Postoperative Cognitive Dysfunction) is associated with increased mortality and disability and may develop as a consequence of lipid peroxidative byproducts (i.e. acrolein), which accumulate with aging. ...