Do statins alter the risk or progression of dementia?
Q: Do statins alter the risk or progression of dementia? Evidence-based answer: No. Moderate-intensity statin therapy (with pravastatin or simvastatin) doesn’t prevent progression to dementia in patients at increased risk. No prevention studies address high-intensity statin therapy (strength of recommendation [SOR]: A, randomized controlled trials [RCTs]). Neither moderate- nor high-intensity statin therapy (with simvastatin or atorvastatin, respectively) improves existing mild to moderately severe Alzheimer’s or vascular dementia (SOR: A, RCTs). Although statin use is associated with a mild, rare, reversible delirium, it isn’t linked to permanent cognitive decline (SOR: C, expert opinion).
JOURNAL OF FAMILY PRACTICE | SEPTEMBER 2018 | VOL 67, NO 9: 578-579.