Do statins alter the risk or progression of dementia?
Abstract
Q: Do statins alter the risk or progression of dementia? Evidence-based answer: No. Moderate-intensity statin therapy (with pravastatin or simvastatin) doesn't prevent progression to dementia in patients at increased risk. No prevention studies address high-intensity statin therapy (strength of recommendation [SOR]: A, randomized controlled trials [RCTs]). Neither moderate- nor high-intensity statin therapy (with simvastatin or atorvastatin, respectively) improves existing mild to moderately severe Alzheimer's or vascular dementia (SOR: A, RCTs). Although statin use is associated with a mild, rare, reversible delirium, it isn't linked to permanent cognitive decline (SOR: C, expert opinion).
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