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dc.contributor.advisorFadel, Paul J.eng
dc.contributor.authorNelson, Jasmine N.eng
dc.date.issued2009eng
dc.date.submitted2009 Falleng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on January 5, 2010).eng
dc.descriptionThesis advisor: Paul J. Fadel.eng
dc.description"December 2009"eng
dc.descriptionMU: Access is limited to the campuses of the University of Missouri.eng
dc.descriptionM.S. University of Missouri-Columbia 2009.eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Despite avid attempts, non-surgical methods such as diet aids, behavioral modification and exercise are typically unsuccessful in achieving long term weight loss in the obese. However, bariatric surgery maintains a 65 percent success rate making it the most effective means of sustained weight loss. A primary metabolic impairment with obesity is insulin resistance (IR), which has been shown to be associated with impaired cardiac autonomic function. Recent studies have indicated that there are marked improvements in IR, within days of bariatric surgery even before significant weight loss occurs. On the other hand, cardiac autonomic function has not been studied immediately after bariatric surgery, although improvements in autonomic function have been demonstrated at later time points (i.e., 6 to 12 months post surgery) when significant weight loss has occurred. Moreover, the relationship between IR and cardiac autonomic function has not been explored following surgically-induced weight loss. Therefore, we hypothesized that a minimal weight reduction induced by bariatric surgery will produce restoration of cardiac autonomic control associated with improvements in IR. We tested six morbidly obese subjects (42[plus-minus sign]3 years) before and one month after Rouxen- Y Gastric Bypass surgery. Our findings suggest that despite marked reductions in body weight (158[plus-minus sign]15 pre vs. 139[plus-minus sign]12 post Kg; P=0.001) and improvements in insulin resistance (7.2[plus-minus sign]1.4 pre vs. 5.1[plus-minus sign]0.9 post; P=0.038) one month following bariatric surgery, cardiac autonomic function and baroreflex sensitivity are unaltered. Therefore, there was no significant short term effect of bariatric surgery on cardiac autonomic control.eng
dc.description.bibrefIncludes bibliographical referenceseng
dc.identifier.oclc496011971eng
dc.identifier.urihttps://doi.org/10.32469/10355/6658eng
dc.identifier.urihttps://hdl.handle.net/10355/6658
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2009 Theseseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.subject.lcshObesity -- Surgeryeng
dc.subject.lcshBaroreflexeseng
dc.subject.lcshInsulin resistanceeng
dc.subject.lcshCardiovascular system -- Physiologyeng
dc.subject.meshBariatric Surgeryeng
dc.subject.meshCardiovascular Physiological Processeseng
dc.subject.meshBaroreflexeng
dc.subject.meshInsulin Resistanceeng
dc.titleMetabolic and autonomic nervous system effects of bariatric surgeryeng
dc.typeThesiseng
thesis.degree.disciplinePhysiology (Medicine) (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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