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dc.contributor.advisorPolo-Parada, Luisen_US
dc.contributor.authorModgi, Amolen_US
dc.date.issued2008eng
dc.date.submitted2008 Fallen
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.en_US
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on September 25, 2009).en_US
dc.descriptionThesis advisor: Dr. Luis Polo Parada.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionM.S. University of Missouri--Columbia 2008.en_US
dc.description.abstractHeart is one of the most important organs of the body and also it is one of the first organs during to the development. The electrical activity of heart is essential for its function. It has been shown that the sodium-calcium exchanger (NCX) is an important exchanger for calcium homeostasis. We hypothesize that the NCX may be present during development. To test this hypothesis we recorded the spontaneous electrical activity of heart from the embryonic chicken heart before and after blocking NCX during different stages of development with different concentration of KB-R7943. We found that the blocking of this exchanger does have significant effect on the amplitude and the rise time of AP. We found out that changes in duration of AP were less in atrium in early stages of development and increased during later stages of development. Interestingly these results were opposite in ventricles where increase in duration of AP was more during early stages of development and decreased during later stages of development. Similarly there was an increase in decay time of atrium and ventricular action potential at different stages of development. There were relatively few very significant changes in rise time of AP. Hence it is quite apparent that the blocking of NCX affects the plateau phase of AP or the calcium extrusion phase. It is also certain that NCX is one of the exchangers present in early embryonic hearts to actively play role in shaping the electrical activity.en_US
dc.format.extentvii, 67 pagesen_US
dc.identifier.merlin.b71543491en_US
dc.identifier.oclc439892810en_US
dc.identifier.otherModgiA-123008-T11810en_US
dc.identifier.urihttp://hdl.handle.net/10355/6671
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartofcollection2008 Freely available theses (MU)
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2008 Theses
dc.source.originalSubmitted by University of Missouri--Columbia Graduate School.eng
dc.subject.lcshChickens -- Embryologyen_US
dc.subject.lcshHeart -- Growthen_US
dc.subject.lcshElectrocardiographyen_US
dc.subject.lcshHeart conduction systemen_US
dc.titleThe role of sodium-calcium exchanger in the electrical activity of embryonic chicken hearten_US
dc.typeThesisen_US
thesis.degree.disciplineBiological engineering (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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