The role of sodium-calcium exchanger in the electrical activity of embryonic chicken heart

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The role of sodium-calcium exchanger in the electrical activity of embryonic chicken heart

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dc.contributor.advisor Polo-Parada, Luis en_US
dc.contributor.author Modgi, Amol en_US
dc.date.accessioned 2010-03-23T17:33:16Z
dc.date.available 2010-03-23T17:33:16Z
dc.date.issued 2008 en_US
dc.date.submitted 2008 Fall en
dc.identifier.other ModgiA-123008-T11810 en_US
dc.identifier.uri http://hdl.handle.net/10355/6671
dc.description The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. en_US
dc.description Title from PDF of title page (University of Missouri--Columbia, viewed on September 25, 2009). en_US
dc.description Thesis advisor: Dr. Luis Polo Parada. en_US
dc.description Includes bibliographical references. en_US
dc.description M.S. University of Missouri--Columbia 2008. en_US
dc.description.abstract Heart is one of the most important organs of the body and also it is one of the first organs during to the development. The electrical activity of heart is essential for its function. It has been shown that the sodium-calcium exchanger (NCX) is an important exchanger for calcium homeostasis. We hypothesize that the NCX may be present during development. To test this hypothesis we recorded the spontaneous electrical activity of heart from the embryonic chicken heart before and after blocking NCX during different stages of development with different concentration of KB-R7943. We found that the blocking of this exchanger does have significant effect on the amplitude and the rise time of AP. We found out that changes in duration of AP were less in atrium in early stages of development and increased during later stages of development. Interestingly these results were opposite in ventricles where increase in duration of AP was more during early stages of development and decreased during later stages of development. Similarly there was an increase in decay time of atrium and ventricular action potential at different stages of development. There were relatively few very significant changes in rise time of AP. Hence it is quite apparent that the blocking of NCX affects the plateau phase of AP or the calcium extrusion phase. It is also certain that NCX is one of the exchangers present in early embryonic hearts to actively play role in shaping the electrical activity. en_US
dc.format.extent vii, 67 pages en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.subject.lcsh Chickens -- Embryology en_US
dc.subject.lcsh Heart -- Growth en_US
dc.subject.lcsh Electrocardiography en_US
dc.subject.lcsh Heart conduction system en_US
dc.title The role of sodium-calcium exchanger in the electrical activity of embryonic chicken heart en_US
dc.type Thesis en_US
thesis.degree.discipline Biological engineering en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name M.S. en_US
thesis.degree.level Masters en_US
dc.identifier.merlin .b71543491 en_US
dc.identifier.oclc 439892810 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2008 Theses
dc.relation.ispartofcollection 2008 Freely available theses (MU)


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