Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2017 Dissertations (MU)
    • 2017 MU dissertations - Freely available online
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2017 Dissertations (MU)
    • 2017 MU dissertations - Freely available online
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Clinical translation of nanomaterials for early detection of genetic abnormalities in fetus and retinopathy in neonates and adults

    Ghoshdastidar, Shreya
    View/Open
    [PDF] research.pdf (5.121Mb)
    [PDF] public.pdf (12.15Kb)
    Date
    2017
    Format
    Thesis
    Metadata
    [+] Show full item record
    Abstract
    Nuclear medicine covers a wide variety of radionuclides to meet demands of disease. In the current study, first we have looked at the application of mono-amine mono-amide ligands for Re(V), 99mTc(V), and 186Re(V) with respect to bombesin for receptor targeting in the pancreas. While procedures for synthesizing 99mTc complexes is similar to other reported procedures, rhenium complexes were synthesized using [ReO(citrate)2] - as the starting material, simplifying purification and isolation. Further studies for the 222-MAMA-BBN complex set included biodistribution studies, which determined that the 99mTc-BBN complex binds to GRP receptors in the pancreas, [about]3% ID/g. The 323-MAMA complex and derivatives were investigated to determine if the 222- or the 323-MAMA backbone provide: an easier preparation, a better framework for chelating given metals, and better transport as a targeting receptor. It is found that, in comparative studies, the 222-MAMA derivates are more preferred in chelation. However, in either case, once the metal is chelated, there is no conversion of products upon the addition of a more preferred ligand system. Another avenue of target therapy being pursued is the study of 105Rh. We are specifically looking at the study of chelation with tetrathioether complexes, to rhodium(III) to translate to the radiotracer scale. Three product isomers are formed in the reaction of rhodium, using SnCl2, with 222-S4-diAcOH. The carboxylate arm can either be free dangling, one bound to the metal, or both (removing bound chlorides respectively); all of these isomers can be easily separated using HPLC. These three species will be avoided when translated to the ligand bombesin analog. Future research in this area will be done with the 105Rh radiotracer for biological applications.
    URI
    https://hdl.handle.net/10355/66724
    https://doi.org/10.32469/10355/66724
    Degree
    Ph. D.
    Thesis Department
    Biological engineering (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • 2017 MU dissertations - Freely available online
    • Biological Engineering electronic theses and dissertations - CAFNR (MU)
    • Biological Engineering electronic theses and dissertations - Engineering (MU)

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems