[-] Show simple item record

dc.contributor.authorVenkitachalam, Lakshmi
dc.contributor.authorGosch, Kensey L.
dc.contributor.authorLipska, Kasia
dc.contributor.authorInzucchi, Silvio E.
dc.contributor.authorGoyal, Abhinav
dc.contributor.authorSpertus, John A.
dc.contributor.authorMasoudi, Frederick A.
dc.contributor.authorJones, Phillip G.
dc.contributor.authorKosiborod, Mikhail
dc.contributor.corporatenameUniversity of Missouri (System)en
dc.contributor.meetingnameMissouri Life Sciences Summit (2010: University of Missouri--Kansas City)en
dc.date.issued2010-03-26T14:46:46Z
dc.descriptionPoster sesssionen
dc.description.abstractBackground: Elevated blood glucose (BG) is associated with an adverse prognosis in acute myocardial infarction (AMI) patients. While guidelines recommend insulin therapy to lower markedly elevated BG in AMI patients, it is unknown whether these recommendations have impacted BG management over time. Methods: We studied 39,775 AMI patients hospitalized from 2000 to 2008 in 55 US medical centers contributing to Health Facts, a national database with extensive data on in-hospital BG and insulin use. Using all available BG measures during the hospital stay, we restricted our analysis to patients with a mean BG ≥200mg/dl and examined temporal trends in insulin use with hierarchical logistic regression models. Results: Overall, 4330 patients (11% of the entire cohort) had mean hospitalization BG ≥ 200 mg/dL and this proportion decreased from 2000 to 2008 (12% to 8%, p for trend<0.001); 75% of these patients had diabetes. In total, 61% of AMI patients with mean BG ≥ 200 received any insulin and only 16% received intravenous (IV) insulin during hospitalization. Hierarchical multivariable models showed an increased likelihood of insulin use over time (Figure). However, about one in three patients continued to receive no treatment for markedly elevated BG. Conclusions: Despite some improvement over time, insulin treatment rates among hospitalized AMI patients with severe, sustained hyperglycemia remain low. These findings likely reflect continuing uncertainty regarding optimal BG management during AMI.en
dc.identifier.urihttp://hdl.handle.net/10355/6701
dc.relation.ispartofAbstracts (Missouri Regional Life Sciences Summit 2010)en
dc.relation.ispartofcommunityUniversity of Missouri System. Missouri Summits. Missouri Regional Life Sciences Summit 2010
dc.subjectblood glucoseen
dc.subjectinsulin therapyen
dc.subjectlogistic regression modelsen
dc.subject.lcshLogistic regression analysisen
dc.subject.lcshBlood sugaren
dc.titleTemporal trends in the management of severe hyperglycemia among patients hospitalized with acute myocardial infarction [abstract]en
dc.typeAbstracten


Files in this item

[PDF]

This item appears in the following Collection(s)

[-] Show simple item record