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    Novel Nanostructured Organosilicate Nanoparticle Coatings for Chem-Bio Sensing [abstract]

    Korampally, Venumadhav, 1972-
    Darr, Charles Matthew, 1984-
    Polo-Parada, Luis
    Gangopadhyay, Keshab
    Gangopadhyay, Shubhra
    Grant, Sheila Ann
    Sobel, Annette
    Singh, Balram
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    [PDF] NovelNanostructuredOrganosilicate[abstract].pdf (20.19Kb)
    Date
    2010-03
    Contributor
    University of Missouri (System)
    Format
    Abstract
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    Abstract
    We present novel nanostructured organosilicate particulate based films and demonstrate that these materials have a great potential for chemical-biological sensor development. With unprecedented high surface areas (> 1400 m2/g) and optical transparency together with its easy surface functionalization, these materials can be readily interfaced with existing immunoassays for the rapid and trace detection of both chemical and biological warfare agents. The ultra high surface area associated with these films stems from its unique nanostructure consisting of nanoparticles (2-5nm) in a “raspberry” structure in combination with interconnected nanopores (3-10nm). This unique nanostructure has been exploited to immobilize high areal density of sensor probes to improve the sensing performance. Two orders of magnitude increase in binding density was achieved when fluorescently tagged protein A molecules were immobilized upon these surfaces compared to flat substrates (glass and Silicon). Our on-going work applies these materials to develop platforms for multiplexed sensitive detection of biological and chemical agents at point of care for both army and civilian use.
    URI
    http://hdl.handle.net/10355/6702
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • Abstracts (Missouri Regional Life Sciences Summit 2010)
    • Electrical Engineering and Computer Science presentations (MU)
    • Biological Engineering presentations (MU)
    • Nano/Micro Systems and Nanotechnology presentations (MU)
    • Dalton Cardiovascular Research Center presentations and publications (MU)

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