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dc.contributor.authorKorampally, Venumadhav, 1972-
dc.contributor.authorDarr, Charles
dc.contributor.authorPolo-Parada, Luis
dc.contributor.authorGangopadhyay, Keshab
dc.contributor.authorGangopadhyay, Shubhra
dc.contributor.authorGrant, Sheila Ann
dc.contributor.authorSobel, Annette
dc.contributor.authorSingh, Balram
dc.contributor.corporatenameUniversity of Missouri (System)en
dc.contributor.meetingnameMissouri Life Sciences Summit (2010: University of Missouri--Kansas City)en
dc.date.issued2010-03eng
dc.descriptionPlenary speakeren
dc.description.abstractWe present novel nanostructured organosilicate particulate based films and demonstrate that these materials have a great potential for chemical-biological sensor development. With unprecedented high surface areas (> 1400 m2/g) and optical transparency together with its easy surface functionalization, these materials can be readily interfaced with existing immunoassays for the rapid and trace detection of both chemical and biological warfare agents. The ultra high surface area associated with these films stems from its unique nanostructure consisting of nanoparticles (2-5nm) in a “raspberry” structure in combination with interconnected nanopores (3-10nm). This unique nanostructure has been exploited to immobilize high areal density of sensor probes to improve the sensing performance. Two orders of magnitude increase in binding density was achieved when fluorescently tagged protein A molecules were immobilized upon these surfaces compared to flat substrates (glass and Silicon). Our on-going work applies these materials to develop platforms for multiplexed sensitive detection of biological and chemical agents at point of care for both army and civilian use.en
dc.identifier.urihttp://hdl.handle.net/10355/6702
dc.relation.ispartofcollectionAbstracts (Missouri Regional Life Sciences Summit 2010)
dc.relation.ispartofcommunityUniversity of Missouri System. Missouri Summits. Missouri Regional Life Sciences Summit 2012
dc.subjectchemical-biological sensoren
dc.subjectimmunoassayen
dc.subjectnanoparticlesen
dc.subject.lcshBiosensorsen_US
dc.subject.lcshImmunoassayen_US
dc.subject.lcshNanoparticlesen_US
dc.titleNovel Nanostructured Organosilicate Nanoparticle Coatings for Chem-Bio Sensing [abstract]en
dc.typeAbstracten


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