[-] Show simple item record

dc.contributor.authorKorampally, Venumadhav, 1972-eng
dc.contributor.authorDarr, Charleseng
dc.contributor.authorPolo-Parada, Luiseng
dc.contributor.authorGangopadhyay, Keshabeng
dc.contributor.authorGangopadhyay, Shubhraeng
dc.contributor.authorGrant, Sheila Anneng
dc.contributor.authorSobel, Annetteeng
dc.contributor.authorSingh, Balrameng
dc.contributor.corporatenameUniversity of Missouri (System)eng
dc.contributor.meetingnameMissouri Life Sciences Summit (2010: University of Missouri--Kansas City)eng
dc.date.issued2010-03eng
dc.descriptionPlenary speakereng
dc.description.abstractWe present novel nanostructured organosilicate particulate based films and demonstrate that these materials have a great potential for chemical-biological sensor development. With unprecedented high surface areas (> 1400 m2/g) and optical transparency together with its easy surface functionalization, these materials can be readily interfaced with existing immunoassays for the rapid and trace detection of both chemical and biological warfare agents. The ultra high surface area associated with these films stems from its unique nanostructure consisting of nanoparticles (2-5nm) in a “raspberry” structure in combination with interconnected nanopores (3-10nm). This unique nanostructure has been exploited to immobilize high areal density of sensor probes to improve the sensing performance. Two orders of magnitude increase in binding density was achieved when fluorescently tagged protein A molecules were immobilized upon these surfaces compared to flat substrates (glass and Silicon). Our on-going work applies these materials to develop platforms for multiplexed sensitive detection of biological and chemical agents at point of care for both army and civilian use.eng
dc.identifier.urihttp://hdl.handle.net/10355/6702eng
dc.languageEnglisheng
dc.relation.ispartofcollectionAbstracts (Missouri Regional Life Sciences Summit 2010)eng
dc.relation.ispartofcommunityUniversity of Missouri System. Missouri Summits. Missouri Regional Life Sciences Summit 2012eng
dc.subjectchemical-biological sensoreng
dc.subjectimmunoassayeng
dc.subjectnanoparticleseng
dc.subject.lcshBiosensorseng
dc.subject.lcshImmunoassayeng
dc.subject.lcshNanoparticleseng
dc.titleNovel Nanostructured Organosilicate Nanoparticle Coatings for Chem-Bio Sensing [abstract]eng
dc.typeAbstracteng


Files in this item

[PDF]

This item appears in the following Collection(s)

[-] Show simple item record