Novel Nanostructured Organosilicate Nanoparticle Coatings for Chem-Bio Sensing [abstract]

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Novel Nanostructured Organosilicate Nanoparticle Coatings for Chem-Bio Sensing [abstract]

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[-] show simple item record Korampally, Venumadhav, 1972- Darr, Charles Polo-Parada, Luis Gangopadhyay, Keshab Gangopadhyay, Shubhra Grant, Sheila Ann Sobel, Annette Singh, Balram 2010-03-26T14:52:16Z 2010-03-26T14:52:16Z 2010-03 eng
dc.description Plenary speaker en
dc.description.abstract We present novel nanostructured organosilicate particulate based films and demonstrate that these materials have a great potential for chemical-biological sensor development. With unprecedented high surface areas (> 1400 m2/g) and optical transparency together with its easy surface functionalization, these materials can be readily interfaced with existing immunoassays for the rapid and trace detection of both chemical and biological warfare agents. The ultra high surface area associated with these films stems from its unique nanostructure consisting of nanoparticles (2-5nm) in a “raspberry” structure in combination with interconnected nanopores (3-10nm). This unique nanostructure has been exploited to immobilize high areal density of sensor probes to improve the sensing performance. Two orders of magnitude increase in binding density was achieved when fluorescently tagged protein A molecules were immobilized upon these surfaces compared to flat substrates (glass and Silicon). Our on-going work applies these materials to develop platforms for multiplexed sensitive detection of biological and chemical agents at point of care for both army and civilian use. en
dc.language.iso en_US en
dc.subject chemical-biological sensor en
dc.subject immunoassay en
dc.subject nanoparticles en
dc.subject.lcsh Biosensors en_US
dc.subject.lcsh Immunoassay en_US
dc.subject.lcsh Nanoparticles en_US
dc.title Novel Nanostructured Organosilicate Nanoparticle Coatings for Chem-Bio Sensing [abstract] en
dc.type Abstract en
dc.contributor.meetingname Missouri Life Sciences Summit (2010: University of Missouri--Kansas City) en
dc.contributor.corporatename University of Missouri (System) en
dc.relation.ispartofcommunity University of Missouri System. Missouri Summits. Missouri Regional Life Sciences Summit 2012
dc.relation.ispartofcollection Abstracts (Missouri Regional Life Sciences Summit 2010)

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