Organization of a gene in drosophila : a progress report : Drosophila melanogaster, rosy Zocus, XDH, genetic fine structure, peptide coding region, cis-acting control element
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The present report summarizes our progress in the genetic dissection of an elementary genetic unit in a higher organism. The rosy locus (ry:3-52.0) in Drosophila melanogaster codes for xanthine dehydrogenase, and is characterized by several classes of induced mutants as well as naturally occurring variants. Pursuing the hypothesis that the rosy locus includes a non-coding, control region as well as a structural element coding for the XDH peptide, experiments have been carried out which place genetic boundaries to the structural element in terms of a map of unambiguous structural element variants. More than sixty sites have been mapped within the boundaries of the structural element. Presently, our research is largely concerned with the elaboration of a cis acting control element located adjacent to the structural element.